Immunostimulation by Brucella abortus. Role of surface antigenicity of the bacteria
| Autor: | Yvonne Le Garrec, Louis Toujas, L. Dazord, Anne de Saint Martin |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Antigenicity
Erythrocytes Brucella Vaccine Brucella abortus Hemolytic Plaque Technique chemical and pharmacologic phenomena Spleen Brucella Microbiology Mice Immune system Antigen medicine Animals biology Immunity General Medicine biology.organism_classification Antibodies Bacterial medicine.anatomical_structure Immunization Antibody Formation biology.protein Female Antibody Bacteria |
| Zdroj: | European Journal of Cancer (1965). 13:493-495 |
| ISSN: | 0014-2964 |
| DOI: | 10.1016/0014-2964(77)90109-8 |
| Popis: | Two suspensions of inactivated B. abortus organisms prepared from either the smooth strain B 19 S or from its rough mutant B 19 R were compared as to their ability to modulate the mouse immune response against sheep red blood cells (SRBC) antigens. The anti SRBC response was measured by counting the number of spleen cells forming hemolytic foci in agar, 4 days after immunization. Referring to this test B. abortus B 19 R revealed more immuno-stimulant than B 19 S. When SRBC and B 19 R were injected at close time intervals, low doses of bacterial organisms were sufficient to enhance the immune response, the optimal effect being obtained for a simultaneous administration of both materials. When SRBC were given 5 or 10 days after Brucella higher doses of organisms were required to modulate the immune response and only B 19 R could increase the number of antibody forming cells. These results were correlated with the difference in surface antigenicity between B 19 R and B 19 S and with the cellular proliferation induced by the two bacterial preparations. |
| Databáze: | OpenAIRE |
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