Vitamin D deficiency and insufficiency among patients with prostate cancer
| Autor: | Manpreet K. Chadha, Annette Sunga, Mary Nesline, Wei Tan, Lili Tian, C. Silliman, Umeer Ashraf, Bruce W. Hollis, Candace S. Johnson, Donald L. Trump, Marwan Fakih |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Urology Gastroenterology Article vitamin D deficiency Body Mass Index Prostate cancer Prostate Internal medicine Vitamin D and neurology Humans Medicine Vitamin D Aged Aged 80 and over Gynecology Performance status business.industry Prostatic Neoplasms Cancer Middle Aged Vitamin D Deficiency medicine.disease medicine.anatomical_structure Case-Control Studies Neoplasm Recurrence Local business Body mass index Blood sampling |
| Zdroj: | BJU International. 104:909-914 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1111/j.1464-410x.2009.08531.x |
| Popis: | OBJECTIVE To assess the frequency of vitamin D deficiency among men with prostate cancer, as considerable epidemiological, in vitro, in vivo and clinical data support an association between vitamin D deficiency and prostate cancer outcome. PATIENTS, SUBJECTS AND METHODS The study included 120 ambulatory men with recurrent prostate cancer and 50 with clinically localized prostate cancer who were evaluated and serum samples assayed for 25-OH vitamin D levels. Then 100 controls (both sexes), matched for age and season of serum sample, were chosen from a prospective serum banking protocol. The relationship between age, body mass index, disease stage, Eastern Cooperative Oncology Group performance status, season and previous therapy on vitamin D status were evaluated using univariate and multivariate analyses. RESULTS The mean 25-OH vitamin D level was 25.9 ng/mL in those with recurrent disease, 27.5 ng/mL in men with clinically localized prostate cancer and 24.5 ng/mL in controls. The frequency of vitamin D deficiency ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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