Traditional risk factors for Helicobacter pylori infection not found among patients undergoing diagnostic upper endoscopy—Republic of Georgia, 2007–2008
| Autor: | Nato Tarkhashvili, Jeremy Sobel, Merab Mirtskhulava, Paata Imnadze, Nana Mebonia, Tamar Chachava, Guram Katsitadze, Ucha Gabunia, Neli Chakvetadze, Vladimer Shengelidze, Lela Bakanidze, Marina Chubinidze, D Kordzaia, Jeannette Guarner |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Rural Population Microbiology (medical) medicine.medical_specialty Urban Population Biopsy Population Stomach Diseases Prevalence Rapid urease test Georgia (Republic) Helicobacter Infections Cohort Studies Young Adult Internal medicine medicine Humans Endoscopy Digestive System Prospective Studies Child Prospective cohort study education Aged Aged 80 and over education.field_of_study Helicobacter pylori biology Histocytochemistry business.industry General Medicine Odds ratio Middle Aged biology.organism_classification Antibodies Bacterial Urease Surgery Logistic Models Infectious Diseases Risk factors Child Preschool Multivariate Analysis Female Gastritis medicine.symptom business Cohort study |
| Zdroj: | International Journal of Infectious Diseases. 16:e697-e702 |
| ISSN: | 1201-9712 |
| Popis: | Summary Objectives Helicobacter pylori causes gastritis, duodenal ulcers, and gastric cancer. Although household crowding, low socioeconomic status (SES), and poor sanitation are associated with infection elsewhere, risk factors of infection in the Republic of Georgia (ROG), a country with a high prevalence rate (>70%), remain unknown. In this study we explored potential risk factors of infection among symptomatic patients in ROG. Methods During 2007–2008, we prospectively recruited 390 subjects with gastrointestinal symptoms referred to five tertiary care centers for diagnostic upper endoscopy. We administered a questionnaire on potential risk factors and tested patients using three diagnostic tests: gastric biopsies underwent histological evaluation and rapid urease test (CLO test), and an ELISA was used to detect IgG against H. pylori in serum. We defined a case as having two or more positive results from the three available tests. Univariate and multivariate logistic regression analyses were performed. Results Overall, 217 (56%) patients met the study case definition. Subjects diagnosed with cancer had the highest rate of H. pylori infection (62%), followed by those with gastritis (55%), and ulcer (54%). Age >30 years (adjusted odds ratio (aOR 2.6, 95% confidence interval (CI) 1.6–4.3) and residing in the capital city (aOR 0.6, 95% CI 0.4–0.9) were significantly associated with infection. Conclusions In this large cohort with gastrointestinal symptoms, only age >30 years and living in the capital were significant factors associated with infection. Lower SES, less education, and crowding did not confer an increased risk, in contrast to the findings of previous studies. Population-based studies are needed to identify potential routes and risk factors of H. pylori infection in ROG. |
| Databáze: | OpenAIRE |
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