Chemotherapy-Induced Peripheral Neuropathy – Epidemiology and Pathogenesis
| Autor: | Maciej Kaźmierczak, Ewa Nowak-Markwitz, Dariusz Iżycki, Adam Andrzej Niezgoda |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pediatrics Activities of daily living medicine.medical_treatment Antineoplastic Agents 03 medical and health sciences 0302 clinical medicine Quality of life Risk Factors Epidemiology medicine Humans Paresthesia Chemotherapy business.industry Peripheral Nervous System Diseases Obstetrics and Gynecology Cancer medicine.disease Surgery Discontinuation Peripheral neuropathy Chemotherapy-induced peripheral neuropathy 030220 oncology & carcinogenesis Female business 030217 neurology & neurosurgery |
| Zdroj: | Polish Gynaecology. 87:293-299 |
| ISSN: | 0017-0011 |
| DOI: | 10.17772/gp/61750 |
| Popis: | Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most important neurologic complications experienced by patients receiving chemotherapy. The neuropathy often interferes with daily activities and exercise leading to severe impairment of the patient's quality of life (QoL). The evolution of most CIPNs is characterized by a gradual onset of signs/symptoms, beginning in the lower limbs and advancing proximally into a bilateral stocking and glove distribution. Patients often complain of numbness, tingling and pain in the affected areas. The symptoms become aggravated with repeated cycles of chemotherapy. When the offending agent is withheld, the symptoms generally abate, but relief is not guaranteed. The consequences of delay or discontinuation of treatment may affect overall patient survival. |
| Databáze: | OpenAIRE |
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