Growth impairment and growth hormone-IGF-1 axis in infantile anorexia nervosa

Autor: Virginia Silvestri, Giampiero I. Baroncelli, Sandra Maestro, Eleonora Dati, Silvano Bertelloni, Silvia Ghione
Rok vydání: 2015
Předmět:
Zdroj: Journal of Pediatric Endocrinology and Metabolism. 28
ISSN: 2191-0251
0334-018X
DOI: 10.1515/jpem-2013-0400
Popis: Infantile anorexia nervosa (AN) is a specific eating disorder of prepubertal children. Poor data are available on growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in this disorder.We report on a boy (4.5 years) with progressive growth impairment. At psychiatric assessment (DC: 0-3 R, AXIS I), he fulfilled all required criteria for diagnosis of infantile AN. Endocrine evaluation suggested impaired peripheral response to GH (high GH and low IGF-1 levels), likely related to energy deficiency.Auxological evaluation was shown as raw data and SDS using Italian reference values. GH secretion was assessed by arginine provocative test; IGFI generation test was done administering recombinant GH (0.05 mg/kg/day for four days). Psychiatric assessment was performed according to the DC:0-3R protocol.Impaired GH-IGF-1 axis may be involved in growth delay of children with infantile AN. A strict collaboration between endocrine pediatricians and child psychiatrists is advisable in the assessment of poor growing children without recognizable organic causes, showing normal/high GH levels and low IGF-1 values.
Databáze: OpenAIRE