Which factors affect the likelihood of miscarriage after single euploid blastocyst transfer?
Autor: | Remzi Abali, Zalihe Yarkiner, Meral Gultomruk, Mustafa Bahceci, Fazilet Kubra Boynukalin, Aylin Mutlu |
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Rok vydání: | 2021 |
Předmět: |
Adult
0301 basic medicine Infertility medicine.medical_specialty Thrombophilia Body Mass Index Miscarriage Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans Hydrosalpinx Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Obstetrics Blastocyst Transfer Obstetrics and Gynecology Middle Aged Embryo Transfer medicine.disease Abortion Spontaneous 030104 developmental biology Reproductive Medicine Female business Live birth Body mass index Developmental Biology |
Zdroj: | Reproductive BioMedicine Online. 42:1187-1195 |
ISSN: | 1472-6483 |
Popis: | Which parameters affect the likelihood of miscarriage after single euploid frozen-thawed blastocyst transfer (FBT)?In this retrospective study, clinical and laboratory data from 1051 single euploid FBTs were evaluated. Exclusion criteria were endocrine or systemic pathologies, uterine anomalies or pathologies, unilateral or bilateral hydrosalpinx, karyotypic abnormalities (either maternal or paternal) or thrombophilia. Patients were divided into two groups according to pregnancy outcome: live birth and miscarriage.Body mass index (BMI) (25.98 ± 0.5 versus 24.36 ± 0.21, P = 0.019), duration of infertility (6.62 ± 0.54 versus 4.92 ± 0.18, P = 0.006) and number of previous miscarriages (1.36 ± 0.13 versus 0.79 ± 0.05, P0.001) were significantly higher in the miscarriage group (n = 100) than in the live birth group (n = 589). Although the trophectoderm and inner cell mass (ICM) percentage scores were not statistically different among the miscarriage and live birth groups, the percentage of day-6 biopsied embryos was significantly higher in the miscarriage group. Binary logistic regression analysis revealed that BMI (OR 1.083, 95% CI 1.013 to 1.158, P = 0.02) and number of previous miscarriages (OR 1.279, 95% CI 1.013 to 1.158, P = 0.038) were independent factors for miscarriage. Patients with elevated BMI and a higher number of miscarriages were at increased risk of miscarriage.After a single euploid FBT, BMI and number of previous miscarriages are predictors of miscarriage. Lifestyle interventions before FBT may decrease miscarriage rates. |
Databáze: | OpenAIRE |
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