Antiplasmodial Oleanane Triterpenoids from Terminalia albida Root Bark
| Autor: | Mohamed Sahar Traore, Aliou Mamadou Balde, Laura Peeters, Luc Pieters, Tom Vermeyen, Mamadou Aliou Baldé, Paul Cos, Wouter A. Herrebout, An Matheeussen, Kenn Foubert, Emmy Tuenter, Guy Caljon |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmaceutical Science
medicine.disease_cause 01 natural sciences Analytical Chemistry chemistry.chemical_compound Drug Discovery medicine Candida albicans Biology Oleanane Pharmacology Combretaceae Traditional medicine biology 010405 organic chemistry Chemistry Pharmacology. Therapy Organic Chemistry Antimicrobial biology.organism_classification Corpus albicans 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Phytochemical Staphylococcus aureus visual_art visual_art.visual_art_medium Molecular Medicine Bark |
| Zdroj: | Journal of natural products |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.0c01119 |
| Popis: | Phytochemical investigation of the n-BuOH extract of the roots of Terminalia albida Sc. Elliot (Combretaceae) led to the isolation and identification of 10 oleanane triterpenoids (1–10), among which six new compounds, i.e., albidanoside A (2), albidic acid A (4), albidinolic acid (5), albidienic acid (8), albidolic acid (9), and albidiolic acid (10), and two triterpenoid aglycones, i.e., albidic acid B (6) and albidic acid C (7), were isolated here for the first time from a natural source, along with two known compounds. The structures of these constituents were established by means of 1D and 2D NMR spectroscopy and ESI mass spectrometry. The isolated compounds were evaluated for their antiplasmodial and antimicrobial activity against the chloroquine-resistant strain Plasmodium falciparum K1, Candida albicans, and Staphylococcus aureus. Compounds 1–4, 6, 7, and 8 showed moderate antiplasmodial activity with IC50 values between 5 and 15 μM. None of the tested compounds were active against C. albicans or S. aureus. These findings emphasize the potential of T. albida as a source for discovery of new antiplasmodial compounds. |
| Databáze: | OpenAIRE |
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