Mutant, wild type, or overall p53 expression: freedom from clinical progression in tumours of astrocytic lineage
| Autor: | Jimmy T. Efird, D M Malkin, Paul Okunieff, D. W. Hsu, R Zeheb, Francisco S. Pardo |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
Cancer Research Prognostic variable Pathology medicine.medical_specialty DNA Mutational Analysis Biology Astrocytoma medicine.disease_cause radiation therapy Polymerase Chain Reaction Epitope Disease-Free Survival Immunoenzyme Techniques 03 medical and health sciences 0302 clinical medicine Risk Factors Glioma medicine Humans Point Mutation Cell Lineage brain tumour Gene glioma survival Polymorphism Single-Stranded Conformational 030304 developmental biology 0303 health sciences Mutation Molecular and Cellular Pathology DNA Neoplasm Middle Aged medicine.disease Prognosis 3. Good health Oncology Massachusetts Tumor progression 030220 oncology & carcinogenesis Disease Progression Female Tumor Suppressor Protein p53 Immunostaining |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Abnormalities of the p53 tumor-suppressor gene are found in a significant proportion of astrocytic brain tumours. We studied tumour specimens from 74 patients evaluated over 20 years at the Massachusetts General Hospital, where clinical outcome could be determined and sufficient pathologic material was available for immunostaining. p53 expression studies employed an affinity-purified p53 monoclonal antibody, whose specificity was verified in absorption studies and, in a minority of cases, a second antibody recognising a different epitope of p53. Significant overexpression of p53 protein was found in 48% of the 74 tumours included in this series and high levels of expression were associated with higher mortality from astrocytic tumours (P |
| Databáze: | OpenAIRE |
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