Comparative enhancement of curcumin cytotoxic photodynamic activity by nanoliposomes and gold nanoparticles with pharmacological appraisal in HepG2 cancer cells and Erlich solid tumor model
| Autor: | Nayera Mohamed El Ghoubary, Maha Fadel, Kawser Kassab, Maha Nasr, Doaa A. Abdel Fadeel |
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| Rok vydání: | 2018 |
| Předmět: |
Male
endocrine system Curcumin medicine.medical_treatment Metal Nanoparticles Pharmaceutical Science Antineoplastic Agents Photodynamic therapy 02 engineering and technology 030226 pharmacology & pharmacy Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Spectroscopy Fourier Transform Infrared Drug Discovery medicine Animals Humans Cytotoxic T cell Photosensitizer Particle Size Carcinoma Ehrlich Tumor Pharmacology Liposome Singlet oxygen Organic Chemistry food and beverages Hep G2 Cells 021001 nanoscience & nanotechnology Drug Liberation Photochemotherapy chemistry Colloidal gold Liposomes Cancer cell Cancer research Nanoparticles 0210 nano-technology |
| Zdroj: | Drug Development and Industrial Pharmacy. 44:1809-1816 |
| ISSN: | 1520-5762 0363-9045 |
| Popis: | Curcumin is a natural pigment that generates singlet oxygen upon light excitation, hence it can be used as a photosensitizer in photodynamic therapy. The extremely low water solubility and poor systemic bioavailability make curcumin a challenging molecule to be used clinically. In this study, two nanocarrier systems for curcumin were prepared and characterized; nanoliposomes and polyvinyl pyrrolidone-capped gold nanoparticles. The dark and photocytotoxicity were investigated as a function of light fluence rate (100 and 200 mW/cm |
| Databáze: | OpenAIRE |
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