Quality of Life following Chemoradiation and Postoperative Radiation for Locally Advanced Head and Neck Cancer
| Autor: | Paul Vos, Shawn Huang, Ulf Karlsson, Harold Wc Ward, Claire Lemanski, Phuc D. Nguyen, Ly M. Nguyen, Sue Rose, Adir Ludin, Sabah Sallah, Nam P. Nguyen, Suresh Dutta |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Soft Tissue Injuries Locally advanced Anxiety Quality of life Surveys and Questionnaires Humans Medicine Single institution Aged Retrospective Studies Aged 80 and over Postoperative Care Radiotherapy business.industry Postoperative radiation Advanced stage Head and neck cancer Middle Aged medicine.disease Combined Modality Therapy humanities Surgery Hospitalization body regions Otorhinolaryngology Head and Neck Neoplasms Esophageal Stenosis Quality of Life Female Radiology business Chemoradiotherapy |
| Zdroj: | ORL. 69:271-276 |
| ISSN: | 1423-0275 0301-1569 |
| DOI: | 10.1159/000103870 |
| Popis: | Background: To evaluate the impact of chemoradiation and postoperative radiation on patients’ quality of life (QOL) in a single institution. Methods: A retrospective analysis of 101 patients who had treatment for locally advanced head and neck cancer in a single institution. Forty-seven patients had chemotherapy and radiation, 54 patients underwent postoperative radiation. QOL was assessed with the University of Washington (UW), and the Hospital Anxiety (HA) and Depression (HD) questionnaires. All patients were free of disease at the survey time. Results: Mean and median UW scores were not different between the 2 groups: chemoradiation (65/67), postoperative radiation (62/63). Mean and median HA scores were 7.6/7 (chemoradiation), and 8.3/8 (postoperative radiation). Mean and median HD scores were 6.7/7 (chemoradiation), and 7.1/7 (postoperative radiation). Forty-four patients developed complications, with mean/median UW, HA, and HD scores of 55/55, 9.9/8, and 8.9/9, respectively. These scores were significantly different compared to the 57 patients without complications: 70/70 (p = 0.0001), 6.5/6 (p = 0.001), and 8.9/9 (p = 0.0001). Conclusion: There was no significant difference in QOL between chemoradiation and postoperative radiation in this retrospective study with a relatively short follow-up in the chemoradiation group. In addition, there were more patients with resectable disease in the postoperative group which may explain the lack of difference in QOL between the two groups. Patients who developed complications following treatment experienced lower QOL, more anxiety and depression. Our study raised the need to conduct a prospective randomized study to assess the real impact of chemoradiation and postoperative radiation on patients’ QOL. |
| Databáze: | OpenAIRE |
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