Effects of Interaction Between Dopamine D2 Receptor and Monoamine Oxidase A Genes on Smoking Status in Young Men
| Autor: | Chen-Nu Liu, Min-Hsuan Lin, Chih-Ling Huang, Wei-Chih Ou, Chia-Chen Lu, Pei-Lain Chen, Yi-Chun Chen, Mei-Chih Chen, Ching-Shan Huang |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Biological Research For Nursing. 17:422-428 |
| ISSN: | 1552-4175 1099-8004 |
| DOI: | 10.1177/1099800415589366 |
| Popis: | Although the effect of gene–gene interaction on nicotine–dopamine metabolism for smoking behavior has been reported, polymorphisms of dopamine D2 receptor ( DRD2) and monoamine oxidase A ( MAOA) have not been simultaneously examined among smokers. In this study, 481 young Taiwanese men completed a self-report questionnaire on smoking status, and data were obtained on polymorphisms of DRD2 rs1800497, DRD2 rs1079597, MAOA rs309850, and MAOA rs1137070, urinary nicotine, and urinary cotinine. In a comparison of 261 current smokers and 220 never smokers, odds ratios ( ORs) for the development of smoking in all genotypes were not statistically significant. Among smokers with DRD2 rs1079597 GG// MAOA rs309850 3-repeat, the OR of heavier smoking was 2.67 times higher (95% confidence interval [CI]: [1.08, 6.59], p = .031) and the score on the Fagerstrom test for nicotine dependence was higher (4.26 vs. 2.83) than in those with DRD2 rs1079597 AA// MAOA rs309850 3-repeat. Adjusted urinary cotinine concentration was significantly different between those two groups (median value: 95.83 ng/μl vs. 133.24 ng/μl, respectively, p = .045). These findings suggest that the interaction of DRD2 rs1079597 and MAOA rs309850 3-repeat affects smoking intensity in young Taiwanese men. |
| Databáze: | OpenAIRE |
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