Mortality and causes of death among users of methadone maintenance treatment in Israel, 1999–2008
| Autor: | Paula Rosca, Peres Zohar, Nehama Goldberger, Alexander M. Ponizovsky, Anatoly Margolis, Ziona Haklai |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Narcotics Methadone maintenance Adolescent Databases Factual Population Emigrants and Immigrants Toxicology Cohort Studies Young Adult Sex Factors Cause of Death mental disorders Confidence Intervals Ethnicity Opiate Substitution Treatment medicine Humans Pharmacology (medical) Israel education Pharmacology Excess mortality education.field_of_study business.industry Mortality rate Age Factors Nationwide database Middle Aged Opioid-Related Disorders Confidence interval Psychiatry and Mental health Cohort Female Medical Record Linkage business Methadone Demography medicine.drug |
| Zdroj: | Drug and Alcohol Dependence. 125:160-163 |
| ISSN: | 0376-8716 |
| DOI: | 10.1016/j.drugalcdep.2012.03.013 |
| Popis: | Objectives To determine all-cause and specific-causes mortality, in the years 1999–2008, among opioid-dependent users treated at methadone maintenance treatment (MMT) clinics in Israel and to compare the obtained results with data from relevant studies worldwide. Method The records of patients treated at MMT units were linked to the nationwide database of causes of death. Information about the Israeli general population from the Central Bureau of Statistics was used for comparison to match sex and age to the cohort under study. Crude mortality rates (CMRs) per 100 persons per year (PY) and standardized mortality ratios (SMRs) with 95% confidence intervals (CIs) were calculated. Results The overall CMR for MMT users was 1.49/100 PY (CI 1.40–1.59) and was not associated with gender, age at entering MMT, ethnicity, and immigrant status. The leading causes of mortality were sudden/undefined death (0.31/100 PY, CI 0.26–0.35), overdose (0.22/100 PY, CI 0.17–0.27), and cancer (0.15/100 PY, CI 0.12–0.18). The MMT users were 12.2 times more likely to die from all causes than people from the general population. Overall, our estimates were comparable with the figures pooled from relevant studies. Conclusions The results suggest that the excess mortality of MMT users is associated with an increased morbidity, which alone or in combination with service-related risks, lead to worse outcomes. |
| Databáze: | OpenAIRE |
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