Risk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study

Autor: Anaïs Chartier, Nicholas Moore, A. Grolleau, Régis Lassalle, Sinem Ezgi Gulmez, Ulku Sur Unal
Přispěvatelé: Grolleau, Adeline, CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux PharmacoEpi, Inserm CIC1401, Université de Bordeaux, Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Tekirdağ Çerkezköy Tepe Emlak Family Medicine Centre, This study was supported by an unconditional public joint grant from Direction Générale de la Santé (DGS), from Mission recherche de la Direction de la recherche, des études, de l’évaluation et des statistiques (MiRe-DREES) of Caisse Nationale d’Assurance Maladie des Travailleurs Salariés (CNAMTS), Régime Social Indépendants (RSI) and Caisse Nationale de Solidarité́ pour l’Autonomie (CNSA), as part of the general call for projects by IReSP (Appel à Projets, Institut de Recherche en Santé Publique)., Cette recherche a bénéficié de l’aide conjointe de la Direction Générale de la Santé (DGS), de la Mission recherche de la Direction de la recherche, des études, de l’évaluation et des statistiques (MiRe-DREES) de la Caisse Nationale d’Assurance Maladie des Travailleurs Salariés (CNAMTS), du Régime Social des Indépendants (RSI) et de la Caisse Nationale de Solidarité pour l’Autonomie (CNSA), dans le cadre de l’appel à projets général lancé par l’IReSP (Institut de Recherche en Santé Publique).
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Ketoprofen
Male
Time Factors
pharmacoepidemiology
Databases
Factual
Epidemiology
NOP
étude cas-population
acute liver injury
030226 pharmacology & pharmacy
Case-population study
0302 clinical medicine
Pharmacology (medical)
030212 general & internal medicine
Prospective Studies
Liver injury
education.field_of_study
Anti-Inflammatory Agents
Non-Steroidal
drug-exposed hepatotoxicity
Pharmacoepidemiology
Middle Aged
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Ibuprofen
3. Good health
Hospitalization
[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences
pharmacoépidémiologie
Female
France
Chemical and Drug Induced Liver Injury
medicine.drug
Adult
medicine.medical_specialty
Population
étude sur base de données
03 medical and health sciences
Diclofenac
paracetamol (acetaminophen)
Internal medicine
non-steroidal anti-inflammatory drugs (NSAIDs)
medicine
Humans
paracétamol
anti-inflammatoires non stéroïdiens
education
Acetaminophen
Aged
Dose-Response Relationship
Drug
business.industry
claims database
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
exposition médicamenteuse
medicine.disease
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Liver Transplantation
Transplantation
hépatite aiguë
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
Zdroj: Pharmacoepidemiology and Drug Safety
Pharmacoepidemiology and Drug Safety, Wiley, 2018, 27 (11), pp.1174-1181. ⟨10.1002/pds.4640⟩
ISSN: 1053-8569
1099-1557
DOI: 10.1002/pds.4640⟩
Popis: This is the peer reviewed version of the following article: "Risk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study", which has been published in final form at https://onlinelibrary.wiley.com/doi/full/10.1002/pds.4640.This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.; International audience; Purpose: The SALT study found similar per-user risks of acute liver failure (ALF) leading to transplantation (ALFT) between NSAIDs and a three-fold higher risk in non-overdose paracetamol (NOP) users. The objective of EPIHAM was to identify the risks of hospital admission for acute liver injury (ALI) associated with NSAIDs and NOP. Methods: Case-population study included in the 1/97 sample of the French population claims database. ALI was identified from hospital discharge summaries, from 2009 to 2013. Exposure for cases was dispensation of NSAID or NOP resulting in exposure within 30 days before admission. Population exposure was number of patients using the drugs over the study timeframe and total number of DDD dispensed. Results: Of 63 cases of ALI, 13 had been exposed to NSAIDs and 24 to NOP. Events per million DDD [95%CI] ranged from 0.46 [0.09-1.34] (ketoprofen) to 1.43 [0.04-7.97] (diclofenac combinations), 0.43 [0.23-0.73] all NSAIDs combined, 0.58 [0.37-0.86] for NOP. There was no association with average duration of treatment. Per patient risk ranged from 19.5 [5.31-49.9] (ibuprofen) per million users to 37.2 [19.8-63.6] all NSAIDs combined, 58.0 [37.2-86.3] for NOP. There was a linear relationship between average treatment duration and per-user risk (R2=0.51, p
Databáze: OpenAIRE
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