MicroRNA-27b up-regulated by human papillomavirus 16 E7 promotes proliferation and suppresses apoptosis by targeting polo-like kinase2 in cervical cancer

Autor:	Qian Wang, Zixian Wu, Lei Zheng, Shimeng Zhang, Xin-Ru Mao, Zhen Zhao, Jin-Lan Huang, Fei Liu
Rok vydání:	2016
Předmět:	0301 basic medicine cervical cancer Papillomavirus E7 Proteins Blotting Western Uterine Cervical Neoplasms Apoptosis Protein Serine-Threonine Kinases DGCR8 Antisense nucleic acid 03 medical and health sciences RNA interference polo-like kinase2 Cell Line Tumor microRNA medicine Humans Cell Proliferation Cisplatin Human papillomavirus 16 business.industry Cell growth Gene Expression Profiling RNA-Binding Proteins Cancer HPV16 E7 medicine.disease Virology Up-Regulation Gene Expression Regulation Neoplastic MicroRNAs microRNA-27b 030104 developmental biology Oncology Host-Pathogen Interactions Cancer research Female RNA Interference business Research Paper medicine.drug
Zdroj:	Oncotarget
ISSN:	1949-2553
DOI:	10.18632/oncotarget.7531
Popis:	The infection with high-risk human papillomavirus is linked to cervical cancer, nevertheless, the role of miRNAs regulated by HPV oncogenes in cancer progression remain largely unknown. Here, we knocked down endogenous E6/E7 in HPV16-positive CaSki cell lines, screened differences in miRNA expression profile with control using miRNA array. 38 miRNAs were down-regulated and 6 miRNAs were up-regulated in the E6/E7 silenced CaSki cells (>2-fold changes with P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd6ddba45c5612a25ee7f48e6210b21 https://doi.org/10.18632/oncotarget.7531 Zobrazit plný text záznamu