Cognitive dysfunction in patients with nasopharyngeal carcinoma after induction chemotherapy
Autor: | Jun Wang, Li-E Lin, San-Gang Wu, Hua Zheng, Qin Lin, Chen-Lu Lian, Yi-Feng Yu |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Logistic regression 03 medical and health sciences Young Adult 0302 clinical medicine Cognition Sex Factors Internal medicine medicine Humans Attention Cognitive Dysfunction Prospective Studies 030223 otorhinolaryngology Prospective cohort study Aged Chemotherapy Language Disorders Nasopharyngeal Carcinoma business.industry Incidence (epidemiology) Induction chemotherapy Montreal Cognitive Assessment Nasopharyngeal Neoplasms Induction Chemotherapy Middle Aged medicine.disease Oncology Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Educational Status Regression Analysis Female Oral Surgery business |
Zdroj: | Oral oncology. 111 |
ISSN: | 1879-0593 |
Popis: | Objective This prospective study aimed to assess the incidence, details of the change of cognitive dysfunction, and predictive factors of cognitive function impairment associated with induction chemotherapy (IC) in nasopharyngeal carcinoma (NPC) patients. Method We prospectively included NPC patients who treated with IC from December 2018 to January 2020. Montreal cognitive assessment (MoCA) was used to measure cognitive function, and score less than 26 was defined as cognitive dysfunction. Multivariate logistic regression analysis was applied to assess the independent predictors associated with cognitive function impairment. Results A total of 76 patients were recruited, 10 patients were excluded due to refusal or unable to finish the questionnaire, and 66 patients were analyzed in this study. The median age of the patients was 48.5 years (range, 24–69 years). There was 89.4% of patients received ≥3 circles of IC. For the entire group, 27.3% had cognitive dysfunction, of which attention, language, short-term memory, and orientation showed significant downward trends, while visuospatial/executive function, naming, and abstraction demonstrated no prominent decrease. In patients having cognitive function impairment, 77.8% of them occurred after the first circle of IC. Gender (P = 0.039) and education (P = 0.03) were significant predictors for cognitive dysfunction. Female patients (female vs. male: 50% vs. 20%) and patients with lower educational levels (lower vs. higher: 37.8% vs. 11.8%) were more likely to suffer cognitive dysfunction. In addition, age (P = 0.572) and chemotherapy circles (P = 0.68) had no association with cognitive dysfunction. Conclusion Approximately 25% of NPC patients suffered cognitive dysfunction after IC, especially in female patients and patients with lower educational levels. |
Databáze: | OpenAIRE |
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