The prognostic effect of anatomic subsite in HPV-positive oropharyngeal squamous cell carcinoma
| Autor: | Peter Costantino, Michael Wotman, Dennis Kraus, Tristan Tham, Ansley M. Roche |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Male medicine.medical_specialty Palatine Tonsil Disease Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Carcinoma Humans Papillomaviridae 030223 otorhinolaryngology Survival rate Aged biology business.industry virus diseases Cancer Middle Aged medicine.disease biology.organism_classification Prognosis female genital diseases and pregnancy complications Lingual tonsils Survival Rate Oropharyngeal Neoplasms medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Cohort Carcinoma Squamous Cell Female business Cohort study SEER Program |
| Zdroj: | American journal of otolaryngology. 40(4) |
| ISSN: | 1532-818X |
| Popis: | Since most HPV-associated disease occurs in the tonsillar-related areas (TRA) - palatine and lingual tonsils, the effect of HPV on survival in non-tonsillar oropharyngeal subsites (nTRA) is not well established. The objective of this study was to use a large population-based cohort to investigate the survival impact of HPV in nTRA subsites versus TRA subsites.This SEER database study was conducted by stratifying the HPV-positive oropharyngeal cancer cohort into two primary groups, TRA and nTRA.HPV-positive squamous cell cancer was significantly more common in TRAs (73%) compared to nTRAs (31.2%, p 0.001). After controlling for age, treatment, stage, race, and income, patients with HPV-positive disease in nTRAs had a worse cause-specific survival (CSS) than individuals with HPV-positive disease in TRAs (HR = 2.16, 95% CI 1.20-3.86, p = 0.01).Patients with HPV-positive OPSCC in nTRAs had poorer survival outcomes compared to patients with HPV-positive OPSCC in TRAs. |
| Databáze: | OpenAIRE |
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