Human duodenal phase III migrating motor complex activity is predominantly antegrade, as revealed by high-resolution manometry and colour pressure plots
| Autor: | J M, Andrews, D G, O'donovan, G S, Hebbard, C H, Malbert, S M, Doran, J, Dent |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Myoelectric Complex Migrating Chi-Square Distribution Duodenum Manometry Endocrine and Autonomic Systems Physiology Chemistry Gastroenterology Phase (waves) Anatomy medicine.anatomical_structure Late phase Pressure medicine Humans Female Peristalsis Pressure analysis Antrum High resolution manometry Migrating motor complex |
| Zdroj: | Neurogastroenterology and Motility. 14:331-338 |
| ISSN: | 1365-2982 1350-1925 |
| DOI: | 10.1046/j.1365-2982.2002.00337.x |
| Popis: | Late phase III migrating motor complex activity has been said to be primarily retroperistaltic but has not been assessed with high resolution manometry or three-dimensional colour pressure plots (pressure/time/distance). Duodenal phase III was examined in healthy young volunteers (seven male, two female) with a 20-lumen assembly. With the most proximal sidehole in the distal antrum, after a 4.5-cm interval 18 sideholes at 1.5-cm intervals spanned the duodenum with a final sidehole 3 cm beyond. Fasting pressures were recorded until phase III occurred. Comparisons were made between proximal (P) and distal (D) duodenum during early (E) (first 0.5-1 min) and late (L) (last 0.5-1 min) phase III. With colour pressure analysis, 121 of 180 pressure wave (PW) sequences were purely antegrade, two purely retrograde and 57 bidirectional. Ten of fifty-seven bidirectional PW sequences were complex, branching to become two separate sequences. Bidirectional sequences occurred more frequently in late than early phase III (L 43 vs. E 14 of 57), but their occurrence did not differ between proximal and distal duodenum (P31 vs. D 24 of 57). Antegrade propagation velocity was faster in late compared with early phase III (L 28.50 vs. E 17.05 mm s(-1); P = 0.006), but did not differ between proximal and distal duodenum. Colour pressure analysis also indicated an intermittent segmental pattern to phase III, with each subject exhibiting a change in velocity or direction, or a relative failure of peristalsis somewhere along the duodenum during part of phase III. Duodenal phase III is not homogenous and, in contrast with previous studies, does not primarily constitute a retroperistaltic pump. Colour pressure analysis is useful in interpreting intraluminal pressure profiles and may improve the sensitivity and specificity of clinical studies. |
| Databáze: | OpenAIRE |
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