Percent Free Prostate Specific Antigen in the Total Prostate Specific Antigen 2 to 4 ng./ml. Range Does Not Substantially Increase the Number of Biopsies Needed to Detect Clinically Significant Prostate Cancer Compared to the 4 to 10 ng./ml. Range
| Autor: | Alexander Haese, Alan W. Partin, Robert T. Dworschack |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Gynecology
medicine.medical_specialty education.field_of_study Prostate biopsy medicine.diagnostic_test business.industry Urology Population Cancer Rectal examination urologic and male genital diseases Percent Free Prostate-Specific Antigen medicine.disease Prostate-specific antigen Prostate cancer medicine.anatomical_structure Prostate medicine education business |
| Zdroj: | The Journal of Urology. :504-508 |
| ISSN: | 0022-5347 |
| DOI: | 10.1097/00005392-200208000-00022 |
| Popis: | Purpose: Percent free prostate specific antigen (PSA) is useful to select patients for prostate biopsy with total PSA 4 to 10 ng./ml. However, 20% of men with PSA between 2.6 and 4 ng./ml. harbor significant prostate cancer and percent free PSA has been suggested to aid in the decision to biopsy in this total PSA range as well. Concerns exist that the number of biopsies needed to detect 1 cancer in this range may be inappropriately high. In a prospective referral population we evaluated sensitivity and specificity of various percent free PSA cutoffs and determined the biopsy-per-cancer ratio in the PSA 2 to 4 ng./ml. range in men with a benign digital rectal examination, and report on the biological nature of the detected cancers based on Gleason score. Results were compared to those obtained from a reference group of patients (PSA 4 to 10 ng./ml., benign digital rectal examination) from the same prospective referral cohort.Materials and Methods: Total PSA and free PSA were measured and percent free PSA w... |
| Databáze: | OpenAIRE |
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