Interrelationships between dietary restriction, the IGF-I axis, and expression of vascular endothelial growth factor by prostate adenocarcinoma in rats
| Autor: | Anna Aleksandra Powolny, Steven K. Clinton, Dahlys R. Hoot, Shihua Wang, Peter S. Carlton |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Cancer Research medicine.medical_specialty medicine.medical_treatment IGFBP3 Gene Expression Enzyme-Linked Immunosorbent Assay Adenocarcinoma Biology medicine.disease_cause Polymerase Chain Reaction Rats Sprague-Dawley Paracrine signalling chemistry.chemical_compound Prostate cancer Prostate Internal medicine medicine Animals Insulin-Like Growth Factor I Autocrine signalling Molecular Biology Caloric Restriction Growth factor Body Weight Prostatic Neoplasms medicine.disease Diet Rats Vascular endothelial growth factor Insulin-Like Growth Factor Binding Protein 3 medicine.anatomical_structure Endocrinology Liver chemistry Carcinogenesis |
| Zdroj: | Molecular Carcinogenesis. 47:458-465 |
| ISSN: | 1098-2744 0899-1987 |
| Popis: | Human studies suggest that excessive energy intake and obesity may influence prostate cancer progression. Rodent experiments demonstrate that diet restriction attenuates tumor growth in parallel with reduced vascular density. The present study examines changes in the insulin-like growth factor I (IGF-I) axis caused by dietary restriction and their association with the expression of vascular endothelial growth factor (VEGF) in prostate cancer. Weanling male Copenhagen rats were randomized into control or 40% dietary restricted groups (n = 5). After 8 wk, rats were implanted with rat AT6.3 prostate adenocarcinoma cells. Two weeks later, the animals were sacrificed and serum, normal prostate, liver, and prostate tumor samples were collected for analyses. Dietary restriction reduced serum concentrations of IGF-I by 35% (P |
| Databáze: | OpenAIRE |
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