Development of antigen cross-presentation capacity in dendritic cells
| Autor: | Yann Leverrier, Christiane Dresch, Jacqueline Marvel, Ken Shortman |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Macrophage colony-stimulating factor
biology Immunology Cross-presentation Dendritic Cells CD8-Positive T-Lymphocytes Granulocyte macrophage colony-stimulating factor Immune system Cross-Priming Antigen MHC class I biology.protein medicine Immunology and Allergy Macrophage Animals Humans Cell Lineage Antigens CD8 medicine.drug |
| Zdroj: | Trends in immunology. 33(8) |
| ISSN: | 1471-4981 |
| Popis: | Cross-presentation by dendritic cells (DCs) of exogenous antigens on MHC class I is important for the generation of immune responses to intracellular pathogens, as well as for maintenance of self tolerance. In mice, the CD8(+) DC lineage is specialised for this role. However, DCs of this lineage are not born with cross-presentation capacity. Several studies have demonstrated that it must be induced as a later developmental step by cytokines such as granulocyte macrophage colony-stimulating factor (GM-CSF), or by microbial products such as toll-like receptor (TLR) ligands. Increased cross-presentation capacity is thus induced in peripheral CD8 lineage DCs during inflammation or infection. However, this capacity is already fully developed in steady-state thymic CD8(+) DCs, in accordance with their role in the deletion of self-reactive developing T cells. |
| Databáze: | OpenAIRE |
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