Assessment of myocardial sympathetic innervation with 18F-FDOPA-PET/CT in patients with autonomic dysfunction: feasibility study in IPD patients
| Autor: | Harish Goyal, C.S. Bal, Chetan Patel, Madhavi Tripathi, Anshul Sharma, Vinay Goyal, Kishore Kumar Deepak, Rajeev Kumar, Priyanka Gupta |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Heart Diseases Primary Dysautonomias 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine 18f fdopa Internal medicine Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging In patient Aged Denervation PET-CT business.industry Mediastinum Dysautonomia Middle Aged Dihydroxyphenylalanine medicine.anatomical_structure Blood pressure Cardiology Feasibility Studies Sympathetic innervation Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 29(3) |
| ISSN: | 1532-6551 |
| Popis: | Dysfunction and denervation of myocardial nor-adrenergic sympathetic neurons has been documented in IPD patients with dysautonomia. The aim of this study was to evaluate the feasibility of single tracer imaging of myocardial sympathetic and cerebral striatal involvement in these patients. Twenty-two controls (mean-age 59.09 ± 12.39 years, 15 men) with no clinical autonomic-dysfunction and normal striatal-uptake in 18F-FDOPA-PET/CT; and 28 patients (mean-age 58.18 ± 8.25 years, 18 men) with autonomic-dysfunction (in Autonomic Function Tests) and striatal dopaminergic-dysfunction were enrolled. Both cardiac-PET/CT (40 minutes post IV-injection of 185-259MBq 18F-FDOPA) and Brain-PET/CT (60 minutes post-IV) were acquired in same session. ROIs were drawn over the entire left ventricular myocardium, individual walls and mediastinum for quantification. Patients and controls were followed-up for 26.93 ± 5.43 months and 37.91 ± 8.63 months, respectively. Striatal and myocardial-parameters were significantly lower in patients compared to controls; with Myocardium/mediastinal ratio (MwMR) yielding the area-under-the-curve of .941 (P |
| Databáze: | OpenAIRE |
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