Dietary arachidonic acid as a risk factor for age-associated neurodegenerative diseases: Potential mechanisms
| Autor: | Jean Luc Olivier, Sandra Pelleieux, Nicolas Vitale, Mélanie H. Thomas |
|---|---|
| Přispěvatelé: | Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty Linoleic acid [SDV]Life Sciences [q-bio] Tau protein tau Proteins Disease Biology Bioinformatics Models Biological Biochemistry ABCA7 neuroinflammation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Alzheimer Disease Risk Factors Internal medicine medicine Humans Neuroinflammation chemistry.chemical_classification Amyloid beta-Peptides Arachidonic Acid Brain General Medicine vitamin f medicine.disease Diet 3. Good health maladie d'alzheimer 030104 developmental biology Endocrinology chemistry biology.protein Arachidonic acid Alzheimer's disease acide arachidonique 030217 neurology & neurosurgery Polyunsaturated fatty acid |
| Zdroj: | Biochimie Biochimie, Elsevier, 2016, 130, pp.168-177. ⟨10.1016/j.biochi.2016.07.013⟩ |
| ISSN: | 0300-9084 |
| Popis: | Alzheimer's disease and associated diseases constitute a major public health concern worldwide. Nutrition-based, preventive strategies could possibly be effective in delaying the occurrence of these diseases and lower their prevalence. Arachidonic acid is the second major polyunsaturated fatty acid (PUFA) and several studies support its involvement in Alzheimer's disease. The objective of this review is to examine how dietary arachidonic acid contributes to Alzheimer's disease mechanisms and therefore to its prevention. First, we explore the sources of neuronal arachidonic acid that could potentially originate from either the conversion of linoleic acid, or from dietary sources and transfer across the blood-brain-barrier. In a second part, a brief overview of the role of the two main agents of Alzheimer's disease, tau protein and Aβ peptide is given, followed by the examination of the relationship between arachidonic acid and the disease. Third, the putative mechanisms by which arachidonic acid could influence Alzheimer's disease occurrence and evolution are presented. The conclusion is devoted to what remains to be determined before integrating arachidonic acid in the design of preventive strategies against Alzheimer's disease and other neurodegenerative diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect