Subregional Basal Forebrain Atrophy in Alzheimer's Disease: A Multicenter Study
| Autor: | Giovanni B. Frisoni, Andreas Fellgiebel, Massimo Filippi, Stefan Klöppel, Rafael Emidio da Silva, Lea T. Grinberg, Stefan J. Teipel, Alex J. Mitchell, Eduardo Joaquim Lopez Alho, Glaucia Aparecida Bento dos Santos, Arun L.W. Bokde, Helmut Heinsen, Ingo Kilimann, Michel J. Grothe, Harald Hampel, Edson Amaro |
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| Přispěvatelé: | Kilimann, I, Grothe, M, Heinsen, H, Alho, Ej, Grinberg, L, Amaro Jr, E, Dos Santos, Ga, da Silva, Re, Mitchell, Aj, Frisoni, Gb, Bokde, Al, Fellgiebel, A, Filippi, Massimo, Hampel, H, Klöppel, S, Teipel, Sj |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Basal Forebrain pathology [Cognitive Dysfunction] pathology [Basal Forebrain] Hippocampus Disease Nucleus basalis Article pathology [Alzheimer Disease] Atrophy Alzheimer Disease medicine Humans Dementia Cognitive Dysfunction ddc:610 etiology [Atrophy] Aged Aged 80 and over Analysis of Variance Basal forebrain General Neuroscience Neurodegeneration complications [Alzheimer Disease] General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology Postmortem Changes Biomarker (medicine) Female Geriatrics and Gerontology complications [Cognitive Dysfunction] Mental Status Schedule Psychology |
| Zdroj: | Journal of Alzheimer's disease 40(3), 687-700 (2014). doi:10.3233/JAD-132345 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Histopathological studies in Alzheimer's disease (AD) suggest severe and region-specific neurodegeneration of the basal forebrain cholinergic system (BFCS). Here, we studied the between-center reliability and diagnostic accuracy of MRI-based BFCS volumetry in a large multicenter data set, including participants with prodromal (n = 41) or clinically manifest AD (n = 134) and 148 cognitively healthy controls. Atrophy was determined using voxel-based and region-of-interest based analyses of high-dimensionally normalized MRI scans using a newly created map of the BFCS based on postmortem in cranio MRI and histology. The AD group showed significant volume reductions of all subregions of the BFCS, which were most pronounced in the posterior nucleus basalis Meynert (NbM). The mild cognitive impairment-AD group showed pronounced volume reductions in the posterior NbM, but preserved volumes of anterior-medial regions. Diagnostic accuracy of posterior NbM volume was superior to hippocampus volume in both groups, despite higher multicenter variability of the BFCS measurements. The data of our study suggest that BFCS morphometry may provide an emerging biomarker in AD. |
| Databáze: | OpenAIRE |
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