Synthesis of 15R-PGD2: a potential DP2 receptor agonist

Autor:	Seongjin Kim, William S. Powell, Joshua Rokach, Kirk M. Maxey, Gue-Jae Lee, Sophie Bellone
Rok vydání:	2005
Předmět:	Agonist Blood Platelets medicine.drug_class Clinical Biochemistry Receptors Prostaglandin Pharmaceutical Science Pharmacology Biochemistry Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Isomerism Drug Discovery medicine Cyclic AMP Receptors Immunologic Receptor Molecular Biology integumentary system Chemistry Prostaglandin D2 Organic Chemistry Total synthesis Biological activity General Medicine Molecular Medicine lipids (amino acids peptides and proteins) Endogenous agonist Hormone
Zdroj:	Bioorganicmedicinal chemistry letters. 15(7)
ISSN:	0960-894X
Popis:	The first total synthesis of 15R-PGD2 3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE2. 15R-PGD2, a potential DP2 receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd1a6f02d1fcb0b9a567b41eadba70b https://pubmed.ncbi.nlm.nih.gov/15780624 Zobrazit plný text záznamu Full Text from ScienceDirect