Serum albumin and the specificity of free tri-iodothyronine as a test for hypothyroidism
| Autor: | M G Rinsler, L Biddulph, David Wright |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
030213 general clinical medicine medicine.medical_specialty Clinical Biochemistry Serum albumin Radioimmunoassay 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Tri iodothyronine Hypothyroidism Reference Values Internal medicine medicine Humans Prospective Studies Serum Albumin Retrospective Studies Bromocresol green biology Chemistry Thyroid disease Albumin General Medicine medicine.disease Endocrinology biology.protein Triiodothyronine Quantitative analysis (chemistry) Hormone |
| Zdroj: | Annals of clinical biochemistry. 26 |
| ISSN: | 0004-5632 |
| Popis: | Serum free tri-iodothyronine (FT3), using two different radioimmunoassays, and serum albumin, using bromocresol green dye-binding method, were measured prospectively in 1374 adults investigated for thyroid disease. The results of similar pairs of measurements in 6608 serum specimens obtained from adults, but using one of the radioimmunoassays for FT3, were examined retrospectively. A close correlation was observed between the FT3 values and serum albumin concentration. Normalisation of the FT3 level using a standard albumin value of 43 g/L in the absence of chemical evidence of hypothyroidism (serum thyrotrophin 3 values which closely resembled that from a normal population. The effects of acute illness and old age, which may lower the FT3 value, can be corrected by this transformation. |
| Databáze: | OpenAIRE |
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