Components of One-carbon Metabolism Other than Folate and Colorectal Cancer Risk
Autor: | Richard Palmqvist, Göran Hallmans, Jörn Schneede, Björn Gylling, Bethany Van Guelpen, Jenny Häggström, Ingegerd Johansson, Per Magne Ueland, Johan Hultdin, Robin Myte |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Male One-carbon metabolism medicine.medical_specialty Epidemiology Colorectal cancer Polymorphism Single Nucleotide Choline 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Folic Acid Methionine Internal medicine Biomarkers Tumor Odds Ratio Medicine Humans Prospective Studies Amino Acids Prospective cohort study Aged Sweden Cancer och onkologi business.industry Follow up studies Case-control study Sarcosine Odds ratio Middle Aged Protective Factors medicine.disease Betaine 030104 developmental biology Endocrinology Logistic Models Folic acid chemistry 030220 oncology & carcinogenesis Case-Control Studies Cancer and Oncology Cancer research Female business Colorectal Neoplasms Biomarkers Follow-Up Studies |
Popis: | BACKGROUND: Despite extensive study, the role of folate in colorectal cancer remains unclear. Research has therefore begun to address the role of other elements of the folate-methionine metabolic cycles. This study investigated factors other than folate involved in one-carbon metabolism, i.e., choline, betaine, dimethylglycine, sarcosine, and methionine and relevant polymorphisms, in relation to the risk of colorectal cancer in a population with low intakes and circulating levels of folate. METHODS: This was a prospective case-control study of 613 case subjects and 1,190 matched control subjects nested within the population-based Northern Sweden Health and Disease Study. We estimated odds ratios (OR) by conditional logistic regression, and marginal risk differences with weighted maximum likelihood estimation using incidence data from the study cohort. RESULTS: Higher plasma concentrations of methionine and betaine were associated with modest colorectal cancer risk reductions (OR [95% confidence interval {CI}] for highest versus lowest tertile: 0.76 [0.57, 0.99] and 0.72 [0.55, 0.94], respectively). Estimated marginal risk differences corresponded to approximately 200 fewer colorectal cancer cases per 100,000 individuals on average. We observed no clear associations between choline, dimethylglycine, or sarcosine and colorectal cancer risk. The inverse association of methionine was modified by plasma folate concentrations (OR [95% CI] for highest/lowest versus lowest/lowest tertile of plasma methionine/folate concentrations 0.39 [0.24, 0.64], Pinteraction = 0.06). CONCLUSIONS: In this population-based, nested case-control study with a long follow-up time from baseline to diagnosis (median: 8.2 years), higher plasma concentrations of methionine and betaine were associated with lower colorectal cancer risk. See Video Abstract at http://links.lww.com/EDE/B83. |
Databáze: | OpenAIRE |
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