Cerebral Vascular Injury in Traumatic Brain Injury
| Autor: | Angela Pronger, Kimbra Kenney, Franck Amyot, Ramon Diaz-Arrastia, Tanya Bogoslovsky, Carol Moore, Margalit Haber |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Traumatic brain injury Pathogenesis 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Animals Humans Medicine business.industry Microcirculation Brain Vascular System Injuries medicine.disease Neurovascular bundle Pathophysiology nervous system diseases Transcranial Doppler Chronic traumatic encephalopathy 030104 developmental biology nervous system Neurology Cerebral blood flow Brain Injuries Cerebrovascular Circulation medicine.symptom business Hypercapnia 030217 neurology & neurosurgery |
| Zdroj: | Experimental Neurology. 275:353-366 |
| ISSN: | 0014-4886 |
| Popis: | Traumatic cerebral vascular injury (TCVI) is a very frequent, if not universal, feature after traumatic brain injury (TBI). It is likely responsible, at least in part, for functional deficits and TBI-related chronic disability. Because there are multiple pharmacologic and non-pharmacologic therapies that promote vascular health, TCVI is an attractive target for therapeutic intervention after TBI. The cerebral microvasculature is a component of the neurovascular unit (NVU) coupling neuronal metabolism with local cerebral blood flow. The NVU participates in the pathogenesis of TBI, either directly from physical trauma or as part of the cascade of secondary injury that occurs after TBI. Pathologically, there is extensive cerebral microvascular injury in humans and experimental animal, identified with either conventional light microscopy or ultrastructural examination. It is seen in acute and chronic TBI, and even described in chronic traumatic encephalopathy (CTE). Non-invasive, physiologic measures of cerebral microvascular function show dysfunction after TBI in humans and experimental animal models of TBI. These include imaging sequences (MRI-ASL), Transcranial Doppler (TCD), and Near InfraRed Spectroscopy (NIRS). Understanding the pathophysiology of TCVI, a relatively under-studied component of TBI, has promise for the development of novel therapies for TBI. |
| Databáze: | OpenAIRE |
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