Relevance of dorsomedial hypothalamus, dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal gray matter in the organization of freezing or oriented and non-oriented escape emotional behaviors
| Autor: | Audrey Francisco Biagioni, Norberto Cysne Coimbra, Ieda Regina dos Santos, Tayllon dos Anjos-Garcia, Farhad Ullah |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Dorsum medicine.medical_specialty N-Methylaspartate Microinjections Emotions Dorsomedial Hypothalamic Nucleus N-Methyl-D-aspartic acid Stimulation Periaqueductal gray Behavioral Neuroscience chemistry.chemical_compound ESTIMULAÇÃO ELÉTRICA Orientation Internal medicine Excitatory Amino Acid Agonists medicine Animals Periaqueductal Gray Rats Wistar Freezing Reaction Cataleptic Analysis of Variance Dose-Response Relationship Drug Panic Rats Endocrinology chemistry Periaqueductal gray matter Ventromedial Hypothalamic Nucleus Hypothalamus NMDA receptor medicine.symptom Psychology Neuroscience |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2015.07.013 |
| Popis: | Electrical stimulation of the periaqueductal gray matter and ventromedial hypothalamus in humans showed the involvement of both these structures in panic attacks. The aim of this work was to make clear the role of dorsal periaqueductal gray (dPAG) matter, dorsomedial hypothalamus (DMH) and the dorsomedial part of the ventromedial hypothalamus (dmVMH) in panic attack-like behaviors. DMH, dmVMH and dPAG of Wistar rats were treated with N-methyl- d -aspartic acid (NMDA) at different doses. The rodents were then kept in a polygonal arena with a burrow to record panic attack-like responses and oriented defensive behaviors. In dmVMH, 6 nmol of NMDA elicited alertness, freezing and oriented escape. The same set of behaviors was elicited by DMH neurons when stimulated by 9 nmol of NMDA. Treatment of dmVMH with 9 nmol of NMDA elicited typical explosive behaviors followed by freezing and oriented behaviors. The stimulation of the dPAG with NMDA at different doses provoked alertness and freezing (1 nmol) or alertness, freezing, tail twitching, explosive behavior and oriented escape (3 nmol), and explosive behavior followed by long-lasting freezing (6 nmol). These data suggest that mainly dPAG plays a role in panic attack-like behaviors that resemble panic syndrome in humans. However, hypothalamic nuclei like dmVMH that mainly elicits oriented escape, can also produce explosive reaction when stimulated with 9 nmol NMDA, whereas, DMH plays a role in coordinating defensive behaviors. |
| Databáze: | OpenAIRE |
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