Effect of Diclofenac on Plasma Levels of Immunoreactive Prolactin, Follicle Stimulating Hormone, Luteinizing Hormone, Thyrotropin, and β-Endorphin in Humans
| Autor: | Jean L. Joris, Paul Franchimont, R. Gathy-Meuleman, Kenneth M Hargreaves, Y. Vrindts-Gevaert, Aimee Reuter |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Diclofenac Endocrinology Diabetes and Metabolism Thyrotropin Gonadotropic cell Basal (phylogenetics) chemistry.chemical_compound Endocrinology Thyrotropic cell Internal medicine medicine Humans Chemistry beta-Endorphin Luteinizing Hormone Prolactin Hormone receptor sense organs Follicle Stimulating Hormone Endocrine gland Hormone |
| Zdroj: | Hormone Research. 29:143-146 |
| ISSN: | 1423-0046 0301-0163 |
| Popis: | Prostaglandins have been shown to modulate the secretion of several pituitary hormones, suggesting that therapeutic doses of nonsteroidal anti-inflammatory drugs may change basal hormone levels. In this study, plasma levels of prolactin, follicle stimulating hormone, luteinizing hormone, thyrotropin and beta-endorphin were determined in 6 healthy men after administration of diclofenac, a prostaglandin synthesis inhibitor. The subjects were given 75 mg intramuscularly and 50 mg orally at 08.00 h the first day, 50 mg orally at 08.00, 12.00 and 20.00 h the second day and an additional 50 mg orally at 08.00 h the third day. Blood samples were collected throughout these 3 days. Diclofenac resulted in a significant and sustained decrease in plasma level of prolactin (p less than 0.005). The other hormones did not demonstrate significant change following diclofenac administration. These data suggest that administration of a prostaglandin synthesis inhibitor, such as diclofenac, selectively alters basal pituitary secretion of prolactin in humans without a detectable effect on plasma levels of other pituitary hormones. This study supports the hypothesis that prostaglandins are necessary for maintaining basal level of prolactin secretion in man. |
| Databáze: | OpenAIRE |
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