Interaction Between Primary Tumor Resection, Primary Tumor Location, and Survival in Synchronous Metastatic Colorectal Cancer: A Population-Based Study
| Autor: | Johannes H. W. de Wilt, Sjoerd G. Elias, Cornelis J A Punt, Miriam Koopman, Auke J. S. van der Kuil, Rob H.A. Verhoeven, Nelleke P.M. Brouwer, Dave E. W. van der Kruijssen, Geraldine R. Vink |
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| Přispěvatelé: | Oncology, CCA - Cancer Treatment and Quality of Life, APH - Methodology, APH - Quality of Care, Internal medicine |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty primary tumor location Colorectal cancer Resection systemic therapy Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Internal medicine Epidemiology Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] medicine Humans 030212 general & internal medicine Aged Netherlands Proportional Hazards Models Retrospective Studies Proportional hazards model business.industry metastatic colorectal cancer Middle Aged medicine.disease Primary tumor Confidence interval primary tumor resection United States Cancer registry Population based study Treatment Outcome 030220 oncology & carcinogenesis Colonic Neoplasms Female business Colorectal Neoplasms SEER Program |
| Zdroj: | American journal of clinical oncology, 44(7), 315-324. Lippincott Williams and Wilkins American Journal of Clinical Oncology: Cancer Clinical Trials, 44(7), 315-324. Lippincott Williams and Wilkins Ltd. American Journal of Clinical Oncology, 44, 315-324 van der Kruijssen, D E W, Brouwer, N P M, van der Kuil, A J S, Verhoeven, R H A, Elias, S G, Vink, G R, Punt, C J A, de Wilt, J H W & Koopman, M 2021, ' Interaction Between Primary Tumor Resection, Primary Tumor Location, and Survival in Synchronous Metastatic Colorectal Cancer: A Population-Based Study ', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 44, no. 7, pp. 315-324 . https://doi.org/10.1097/COC.0000000000000823 American Journal of Clinical Oncology, 44, 7, pp. 315-324 |
| ISSN: | 1537-453X 0277-3732 |
| Popis: | Objectives: Location of the primary tumor has prognostic value and predicts the effect of certain therapeutics in synchronous metastatic colorectal cancer. We investigated whether the association between primary tumor resection (PTR) and overall survival (OS) also depends on tumor location. Methods: Data on synchronous metastatic colorectal cancer patients from the Netherlands Cancer Registry (n=16,106) and Surveillance, Epidemiology, and End Results (SEER) registry (n=19,584) were extracted. Cox models using time-varying covariates were implemented. Median OS for right-sided colon cancer (RCC), left-sided colon cancer, and rectal cancer was calculated using inverse probability weighting and a landmark point of 6 months after diagnosis as reference. Results: The association between PTR and OS was dependent on tumor location (P |
| Databáze: | OpenAIRE |
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