Long-Term Assessment of Bone Regeneration in Nonunion Fractures Treated with Compression-Resistant Matrix and Recombinant Human Bone Morphogenetic Protein-2 in Dogs
| Autor: | Andrea Castilla, Barbro Filliquist, Mathieu Spriet, Tanya C. Garcia, Boaz Arzi, Po-Yen Chou, Amy S. Kapatkin |
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| Rok vydání: | 2022 |
| Předmět: |
Fracture Healing
Bone Regeneration General Veterinary Bone Morphogenetic Protein 2 Ununited compression-resistant matrix Recombinant Proteins Dogs Transforming Growth Factor beta Musculoskeletal Animals Humans Osteoporosis nonunion fracture Animal Science and Zoology Dog Diseases Prospective Studies Veterinary Sciences Bone Fractures rhBMP-2 |
| Zdroj: | Veterinary and comparative orthopaedics and traumatology : V.C.O.T, vol 36, iss 1 |
| ISSN: | 2567-6911 |
| Popis: | Objective The aim of this study was to assess bone density, bone architecture and clinical function of canine nonunion distal appendicular long bone fractures with a defect treated with fixation, compression-resistant matrix and recombinant human bone morphogenetic protein-2 (rhBMP-2). Study Design Prospective cohort study with dogs at least 1-year post treatment. Computed tomography was performed and quantitative measurements from previous fracture sites were compared with measurements from contralateral limbs. Subjective evaluation included gait assessment and palpation. Results Six patients met the inclusion criteria. The rhBMP-2 treated bone exhibited higher density at the periphery and lower density in the centre, similar to the contralateral limb. All patients were weight bearing on the treated limb and all fractures were healed. Conclusion The rhBMP-2-treated bone underwent restoration of normal architecture and density. Acceptable limb function was present in all patients. The results of this study can serve as a basis for long-term response in treating nonunion fractures in veterinary patients. |
| Databáze: | OpenAIRE |
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