Clinical features of sarcoidosis associated pulmonary hypertension: Results of a multi-national registry
| Autor: | Robert P. Baughman, Steven D. Nathan, Joseph Barney, Francis Cordova, Daniel A. Culver, Vasilis Kouranos, Joseph G Cal, Elyse E. Lower, Mary Beth Scholand, JoAnne Baran, Marlies S. Wijsenbeek, Oksana A. Shlobin, Sivagini Ganesh, Surinder S. Birring, Athol U. Wells, Peter J. Engel, Eva M. Carmona, Esam H. Alhamad, Lanier O'Hare |
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| Přispěvatelé: | Pulmonary Medicine |
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Vital capacity medicine.medical_specialty Cardiac Catheterization Sarcoidosis Epidemiology Hypertension Pulmonary Vital Capacity Hemodynamics Walk Test 030204 cardiovascular system & hematology 03 medical and health sciences FEV1/FVC ratio Middle East 0302 clinical medicine Sarcoidosis Pulmonary DLCO medicine.artery Internal medicine medicine Humans Registries Pulmonary wedge pressure Aged Aged 80 and over business.industry X-Rays Sarcoidosis associated pulmonary hypertension Middle Aged medicine.disease Pulmonary hypertension United States Europe medicine.anatomical_structure 030228 respiratory system Pulmonary artery Vascular resistance Cardiology Female business |
| Zdroj: | Respiratory Medicine, 139, 72-78. W.B. Saunders Baughman, R P, Shlobin, O A, Wells, A U, Alhamad, E H, Culver, D A, Barney, J, Cordova, F C, Carmona, E M, Scholand, M B, Wijsenbeek, M, Ganesh, S, Birring, S S, Kouranos, V, O'Hare, L, Baran, J M, Cal, J G, Lower, E E, Engel, P J & Nathan, S D 2018, ' Clinical features of sarcoidosis associated pulmonary hypertension : Results of a multi-national registry ', Respiratory Medicine, pp. 72-78 . https://doi.org/10.1016/j.rmed.2018.04.015 |
| ISSN: | 0954-6111 |
| Popis: | Background Pulmonary hypertension (PH) is a significant cause of morbidity and mortality in sarcoidosis. We established a multi-national registry of sarcoidosis associated PH (SAPH) patients. Methods Sarcoidosis patients with PH confirmed by right heart catheterization (RHC) were studied. Patients with pulmonary artery wedge pressure (PAWP) of 15 mmHg or less and a mean pulmonary artery pressure (mPAP) ≥ 25 Hg were subsequently analyzed. Data collected included hemodynamics, forced vital capacity (FVC), diffusion capacity of carbon monoxide (DLCO), chest x-ray, and 6-min walk distance (6MWD). Results A total of 176 patients were analyzed. This included 84 (48%) cases identified within a year of entry into the registry and 94 (53%) with moderate to severe PH. There was a significant correlation between DLCO percent predicted (% pred) andmPAP (Rho = −0.228, p = 0.0068) and pulmonary vascular resistance (PVR) (Rho = −0.362, p Conclusions The clinical features of SAPH were similar across multiple centers in the US, Europe, and the Middle East. The severity of SAPH was related to reduced DLCO. There were treatment differences between the US and non-US centers. |
| Databáze: | OpenAIRE |
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