Processed human umbilical veins as arterial substitutes — evaluation in canine models
| Autor: | Noel Hp, P Blais, Michel Marois, L. Martin, R. Côté, C. Gosselin, Robert Guidoin, R Bénichoux, F. Laroche |
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| Rok vydání: | 1980 |
| Předmět: |
Umbilical Veins
medicine.medical_specialty Time Factors Materials science medicine.medical_treatment Biophysics Lumen (anatomy) Arterial Occlusive Diseases Bioengineering Anastomosis Prosthesis Biomaterials Fixatives Dogs Suture (anatomy) medicine.artery medicine Animals Humans Thrombus Dialysis medicine.diagnostic_test Abdominal aorta Arteries Anatomy medicine.disease Blood Vessel Prosthesis Surgery Mechanics of Materials Angiography Microscopy Electron Scanning cardiovascular system Ceramics and Composites Blood Flow Velocity |
| Zdroj: | Biomaterials. 1:82-88 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/0142-9612(80)90004-6 |
| Popis: | Human umbilical cord vein segments have been used as vessel substitutes for damaged or occluded arteries, as aorto-coronary by-passes and as arterio-venous fistulae for dialysis. The Dardik-Biograft® fixed with glutaraldehyde and the Mindich-Bioflow®, fixed with ethanol and dialdehyde starch, are commercially available. They were implanted in dogs as replacements for a segment of the abdominal aorta. Post-implantation status was followed by angiography. They were evaluated after removal from sacrificed animals with the aid of scanning electron microscopy and histological techniques. Attention was focused on vessel patency, dimensional stability, integrity of the anastomosis line, lumen wall microstructure, evidence of suture damage and thrombus deposition pattern. Both types of grafts gave functional by-passes for at least until 6 months post-implantation. The Dardik-Biograft® appeared more prone to thrombus formation near the anastomosis. Sparse cellular development was also noted. The Mindich-Bioflow® gave rise to a prosthesis of superior thromboresistance which was more subject to mechanical damage. |
| Databáze: | OpenAIRE |
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