Morphometric Study of Rat Sciatic Nerve Recovery after Three Nerve Repair Techniques: Epineural Suture, Polyethylene Glycol Hydrogel and Fibrin Sealant

Autor:	O Goncharuk-Oleksii, V Medvediev-Volodymyr, I Savosko-Serhii, I Petriv-Taras, I Tsymbaliuk-Vitaly
Rok vydání:	2021
Předmět:	Polyethylene glycol biology business.industry Sealant Sciatic nerve Polyethylene Glycol Hydrogel Fibrin Epineural suture Suture (anatomy) biology.protein Regeneration Medicine Fibrin glue Anatomy business Nerve repair Biomedical engineering
Zdroj:	International Journal of Morphology v.39 n.3 2021 SciELO Chile CONICYT Chile instacron:CONICYT
ISSN:	0717-9502
DOI:	10.4067/s0717-95022021000300677
Popis:	SUMMARY: The effectiveness of microsurgical technique has a direct impact on the recovery of the injured peripheral nerve. The aim of our study was to investigate the result of sciatic nerve regeneration in rats after complete neurotomy and after nerve repair techniques including: 1) epineural suture; 2) polyethylene glycol hydrogel (PEG) (DuraSeal); 3) fibrin sealant (Tisseel). The cross-section of distal sciatic nerve was studied at 14th, 30th and 60th days after nerve repair. Morphometry of myelinated nerve fibers in the distal stump of the sciatic nerve was performed. A significant increase in the number of myelinated nerve fibers was found, especially between 14 and 30 days. The density of myelinated nerve fibers in the distal stump at day 60 was significantly higher after using nerve repair technique including PEG and fibrin versus epineural suture (29.2 % and 32.1 % versus 21.5 %, P
Databáze:	OpenAIRE
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