Gut microbiota of bats: pro-mutagenic properties and possible frontiers in preventing emerging disease
| Autor: | Elizaveta D Kulaeva, Sergey N Golovin, Tatiana I Tverdokhlebova, Igor V. Popov, Michael L. Chikindas, Anna V. Aleshukina, Maria S Mazanko, Alexey Ermakov, Aleksey V Malinovkin, Iraida S Aleshukina, E. V. Prazdnova |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Disease reservoir
DNA damage Science Mutagenesis (molecular biology technique) Bacillus Biosensing Techniques Biology Gut flora medicine.disease_cause Bacterial physiology Microbiology Antiviral Agents Virus Article Antioxidants Mass Spectrometry Feces Immune system Bacterial Proteins Chiroptera Zoonoses Animal physiology medicine Escherichia coli Animals Lactic Acid Disease Reservoirs Inflammation Multidisciplinary SARS-CoV-2 COVID-19 DNA biology.organism_classification Gastrointestinal Microbiome Oxidative Stress Rec A Recombinases Mutagenesis Immune System Viruses Medicine Bacteria DNA Damage Mutagens |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Bats are potential natural reservoirs for emerging viruses, causing deadly human diseases, such as COVID-19, MERS, SARS, Nipah, Hendra, and Ebola infections. The fundamental mechanisms by which bats are considered “living bioreactors” for emerging viruses are not fully understood. Some studies suggest that tolerance to viruses is linked to suppressing antiviral immune and inflammatory responses due to DNA damage by energy generated to fly. Our study reveals that bats' gut bacteria could also be involved in the host and its microbiota's DNA damage. We performed screening of lactic acid bacteria and bacilli isolated from bats' feces for mutagenic and oxidative activity by lux-biosensors. The pro-mutagenic activity was determined when expression of recA increased with the appearance of double-strand breaks in the cell DNA, while an increase of katG expression in the presence of hydroxyl radicals indicated antioxidant activity. We identified that most of the isolated bacteria have pro-mutagenic and antioxidant properties at the same time. This study reveals new insights into bat gut microbiota's potential involvement in antiviral response and opens new frontiers in preventing emerging diseases originating from bats. |
| Databáze: | OpenAIRE |
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