Characteristics of neurological Wilson’s disease with corpus callosum abnormalities
| Autor: | Yong-zhu Han, Gong-qiang Wang, Jin Cao, Yun-Fan Wu, Mingfan Hong, Xue-min Wang, Shu-Hu Liu, Ji-yuan Hu, Zhi-Hua Zhou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology Wilson’s disease Corpus callosum Splenium Gastroenterology lcsh:RC346-429 Neurological dysfunction 03 medical and health sciences 0302 clinical medicine Hepatolenticular Degeneration Internal medicine parasitic diseases medicine Humans Neurochemistry 030212 general & internal medicine Magnetic resonance imaging (MRI) lcsh:Neurology. Diseases of the nervous system Retrospective Studies Unified Wilson’s disease rating scale (UWDRS) business.industry General Medicine medicine.disease Magnetic Resonance Imaging Wilson's disease Globus pallidus Female Neurology (clinical) Liver function Neurosurgery business 030217 neurology & neurosurgery Research Article |
| Zdroj: | BMC Neurology, Vol 19, Iss 1, Pp 1-5 (2019) BMC Neurology |
| ISSN: | 1471-2377 |
| Popis: | Background Wilson’s disease (WD) is an autosomal recessive disease of impaired copper metabolism. Previous study demonstrated that WD with corpus callosum abnormalities (WD-CCA) was limited to the posterior part (splenium). This study aimed to compare clinical features between WD-CCA and WD without corpus callosum abnormalities (WD-no-CCA). Methods Forty-one WD patients who had markedly neurological dysfunctions were included in this study. We retrospectively reviewed clinical, biochemical characteristics and MRI findings in the 41 WD patients. All patients were assessed using the Unified Wilson’s Disease Rating Scale. Results Nine patients had corpus callosum abnormalities, 4 of 9 patients had abnormal signal in the genu and splenium, 5 of 9 patients had abnormal signal only in the splenium. WD-CCA had longer course (9.9 ± 4.0 years vs. 3.4 ± 3.6 years, p |
| Databáze: | OpenAIRE |
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