Parenteral Administration of L-Arginine Prevents Fetal Growth Restriction in Undernourished Ewes
| Autor: | Thomas E. Spencer, Sujay Datta, Guoyao Wu, M. Carey Satterfield, Fuller W. Bazer, Duane H. Keisler, Arantzatzu Lassala, Timothy A. Cudd |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pregnancy Fetus Fetal Growth Retardation Sheep Nutrition and Dietetics Birth weight medicine.medical_treatment Malnutrition Medicine (miscellaneous) Intrauterine growth restriction Biology Arginine medicine.disease Endocrinology Parenteral nutrition Internal medicine medicine Animals Gestation Conceptus Female Nutrient Physiology Metabolism and Nutrient-Nutrient Interactions Saline |
| Zdroj: | The Journal of Nutrition. 140:1242-1248 |
| ISSN: | 0022-3166 |
| DOI: | 10.3945/jn.110.125658 |
| Popis: | Intrauterine growth restriction (IUGR) is a major health problem worldwide that currently lacks an effective therapeutic solution. This study was conducted with an ovine IUGR model to test the hypothesis that parenteral administration of L-arginine (Arg) is effectivein enhancingfetal growth. Beginningon d 28 of gestation, ewes were fed a diet providing100% (control-fed) or 50% (underfed) of NRC-recommended nutrient requirements. Between d 60 of gestation and parturition, underfed ewes received i.v. infusions of saline or 155 mmol Arg-HCl/kg body weight 3 times daily, whereas control-fed ewes received only saline. The birth weights of lambs from saline-infused underfed ewes were 23% lower (P , 0.01) than those of lambs from control-fed dams. Administration of Arg to underfed ewes increased (P , 0.01) concentrations of Arg (69%), ornithine (55%), proline (29%), methionine (37%), leucine (36%), isoleucine (35%), cysteine (19%), and FFA (43%) in maternal serum, decreased maternal circulating levels of ammonia (18%) and triglycerides (32%), and enhanced birth weights of lambs by 21% compared with saline-infused underfed ewes. There was no difference in birth weights of lambs between the control-fed and the Arg-infused underfed ewes. These novel results indicate that parenteral administration of Arg to underfed ewes prevented fetal growth restriction and provide support for its clinical use to ameliorate IUGR in humans. The findings also lay a new framework for studying cellular and molecular mechanisms responsible for the beneficial effects of Arg in regulating conceptus growth and development. J. Nutr. 140: 1242‐1248, 2010. |
| Databáze: | OpenAIRE |
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