Bioadhesive micelles of d -α-tocopherol polyethylene glycol succinate 1000: Synergism of chitosan and transferrin in targeted drug delivery
| Autor: | Sonali, Abhishesh Kumar Mehata, Gunjan Sharma, Madaswamy S Muthu, Poornima Agrawal, Biplob Koch, Sanjay Singh, Chellapa V. Rajesh, Rahul Pratap Singh, Bajarangprasad L Pandey |
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| Rok vydání: | 2017 |
| Předmět: |
Bioadhesive
alpha-Tocopherol Transferrin receptor 02 engineering and technology Polyethylene glycol 010402 general chemistry 01 natural sciences Micelle Polyethylene Glycols Chitosan chemistry.chemical_compound Drug Delivery Systems Colloid and Surface Chemistry Physical and Theoretical Chemistry Micelles chemistry.chemical_classification Transferrin technology industry and agriculture Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Bioavailability chemistry Targeted drug delivery Biochemistry 0210 nano-technology Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 152:277-288 |
| ISSN: | 0927-7765 |
| Popis: | The aim of this work was to prepare targeted bioadhesive d-α- tocopheryl glycol succinate 1000 (TPGS) micelles containing docetaxel (DTX) for brain targeted cancer therapy. Considering the unique bioadhesive feature of chitosan, herein, we have developed a synergistic transferrin receptor targeted bioadhesive micelles using TPGS conjugated chitosan (TPGS-chitosan), which target the overexpressed transferrin receptors of glioma cells for brain cancer therapy. The micelles were prepared by the solvent casting method and characterized for their particle size, polydispersity, zeta-potential, surface morphology, drug encapsulation efficiency, and in-vitro release. The IC50 values demonstrated transferrin receptor targeted TPGS-chitosan micelles could be 248 folds more effective than Docel™ after 24h treatment with the C6 glioma cells. Further, time dependent bioadhesive cellular uptake study indicated that a synergistic effect was achieved with the chitosan and transferrin in targeted TPGS-chitosan micelles through the biodhesive property of chitosan as well as transferrin receptor mediated endocytosis. The in-vivo pharmacokinetic results demonstrated that relative bioavailability of non-targeted and targeted micelles were 2.89 and 4.08 times more effective than Docel™ after 48h of treatments, respectively. |
| Databáze: | OpenAIRE |
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