Antibody-modification of measles 'in vitro' infection
| Autor: | Janine J. Gould, June D. Almeida |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Hemagglutinins
Viral Antibodies Viral Virus Replication Measles Subacute sclerosing panencephalitis Virus Cell Line Inclusion Bodies Viral Cytopathogenic Effect Viral Virology medicine Animals Antigens Viral Antiserum Attenuated vaccine biology Immune Sera Haplorhini medicine.disease Culture Media Infectious Diseases Measles virus Immunology biology.protein Vero cell Antibody Encephalitis |
| Zdroj: | Journal of Medical Virology. 1:111-117 |
| ISSN: | 1096-9071 0146-6615 |
| DOI: | 10.1002/jmv.1890010204 |
| Popis: | While the involvement of measles-like virus with subacute sclerosing panencephalitis (SSPE) has been shown in many laboratories, the possible mechanisms by which a normal measles infection may lead to the chronic condition are unclear. The work reported here demonstrates that the growth and maintenance of Vero cells infected with the MV 30 strain of measles, in the presence of multivalent antibody, results in a redistribution of the viral antigens within the cells and an alteration in the properties of this attenuated virus which persists even after removal of the antiserum from the culture medium. It is suggested that these in vitro findings could be parallel to the situation that occurs in vivo with measles encephalitis in hamsters and human SSPE. |
| Databáze: | OpenAIRE |
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