Longitudinal circulating concentrations of long-chain polyunsaturated fatty acids in the third trimester of pregnancy in gestational diabetes

Autor: Alain Montoudis, Emile Levy, William D. Fraser, Zhong-Cheng Luo, Lin Xiao, Bryna Shatenstein, Jin-Ping Zhao, Anne Monique Nuyt, Pierre Julien, Schohraya Spahis
Rok vydání: 2015
Předmět:
Adult
Fatty Acid Desaturases
0301 basic medicine
medicine.medical_specialty
Docosahexaenoic Acids
Pregnancy Trimester
Third
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
Cohort Studies
Eating
03 medical and health sciences
Delta-5 Fatty Acid Desaturase
0302 clinical medicine
Endocrinology
Pregnancy
Fatty Acids
Omega-6
Diabetes mellitus
Internal medicine
Fatty Acids
Omega-3
Internal Medicine
medicine
Humans
Longitudinal Studies
Prospective Studies
chemistry.chemical_classification
Fetus
030109 nutrition & dietetics
business.industry
Fatty acid
medicine.disease
Dietary Fats
Gestational diabetes
Diabetes
Gestational
chemistry
Docosahexaenoic acid
Case-Control Studies
Pregnancy Trimester
Second
Fatty Acids
Unsaturated
Linear Models
Gestation
Female
business
Polyunsaturated fatty acid
Zdroj: Diabetic Medicine. 33:939-946
ISSN: 0742-3071
DOI: 10.1111/dme.12978
Popis: Aim Gestational diabetes mellitus is a common complication of pregnancy. Long-chain polyunsaturated fatty acids (LCPUFA) are essential for fetal neurodevelopment. Docosahexaenoic acid (DHA) is the predominant n–3 LCPUFA in the brain and retina. Circulating absolute concentrations of total n–3 and n–6 LCPUFAs rise during normal pregnancy. It remains unclear whether gestational diabetes may affect the normal rise in circulating concentrations of LCPUFAs in the third trimester of pregnancy – a period of rapid fetal neurodevelopment. This study aimed to address this question. Methods In a prospective singleton pregnancy cohort, fatty acids in fasting plasma total lipids were measured at 24–28 and 32–35 weeks of gestation in women with (n = 24) and without gestational diabetes mellitus (n = 116). Fatty acid desaturase activity indices were estimated by relevant product-to-precursor fatty acid ratios. Dietary nutrient intakes were estimated by a food frequency questionnaire. Results Plasma absolute concentrations of total n–6 LCPUFAs rose significantly between 24–28 and 32–35 weeks of gestation in women with or without gestational diabetes, whereas total n–3 LCPUFAs and DHA concentrations rose significantly only in women without gestational diabetes (all P < 0.01). Delta–5 desaturase indices (20:4n–6/20:3n–6) were similar, but delta–6 desaturase indices (18:3n–6/18:2n–6) were significantly lower in women with gestational diabetes at 32–35 weeks of gestation. Dietary intakes of all fatty acids were comparable. Conclusion The normal rise in circulating absolute concentrations of DHA and total n–3 LCPUFAs in the third trimester of pregnancy may be compromised in gestational diabetes, probably due to impaired synthesis or mobilization rather than dietary intake difference.
Databáze: OpenAIRE
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