Encapsulation of Drug Molecules into Calix[n]arene Nanobaskets. Role of Aminocalix[n]arenes in Biopharmaceutical Field
| Autor: | Susan E. Matthews, Elena V. Ukhatskaya, Sergey V. Kurkov, Thorsteinn Loftsson |
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| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Metal ions in aqueous solution Supramolecular chemistry Water Pharmaceutical Science Nanoparticle Amino acid Biopharmaceutical Pharmaceutical Preparations Solubility chemistry Calixarene Humans Nanoparticles Structure–activity relationship Organic chemistry Molecule Amino Acids Calixarenes |
| Zdroj: | Journal of Pharmaceutical Sciences. 102:3485-3512 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.23681 |
| Popis: | Calix[n]arenes (CAs) are supramolecular compounds able to form guest-host inclusion complexes with metal ions, small organic molecules, and small moieties of larger molecules. Although the CA literature is extensive, relatively few publications deal with water-soluble CAs, especially those containing nitrogen-based functionality. These CAs possess antibacterial and antifungal activity. Because of their molecular structure, they are surface active and also able to form water-soluble drug complexes, giving additional potential as enabling pharmaceutical excipients. This article provides an overview of the published data regarding synthesis, physicochemical properties, and pharmaceutical application of water-soluble CAs with emphasis on those that contain nitrogen-based substituents in their structure, particularly aminoCAs. In particular, it describes state-of-the-art in complexation of water-soluble CAs with pharmaceutically relevant ions and organic molecules up to amino acids, DNA, and proteins. |
| Databáze: | OpenAIRE |
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