Combination effects of rice extract and five aromatic compounds against α-glucosidase, α-amylase and tyrosinase
| Autor: | Kesinee Nanok, Sompong Sansenya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Tyrosinase Bioengineering 01 natural sciences Applied Microbiology and Biotechnology Hydrocarbons Aromatic 03 medical and health sciences chemistry.chemical_compound 010608 biotechnology medicine Humans Drug Interactions Glycoside Hydrolase Inhibitors Amylase Acarbose chemistry.chemical_classification biology Monophenol Monooxygenase Plant Extracts Vanillin α glucosidase Oryza alpha-Glucosidases 030104 developmental biology Enzyme chemistry Biochemistry biology.protein Guaiacol alpha-Amylases Antagonism Biotechnology medicine.drug |
| Zdroj: | Journal of bioscience and bioengineering. 132(1) |
| ISSN: | 1347-4421 |
| Popis: | Rice is a source of bioactive compounds related to human health and has been used for both consumption and traditional medicine. The authors investigated the synergistic and additive effect of rice extract (RE) combined with five aromatic compounds against three enzymes: α-glucosidase, α-amylase and tyrosinase. RE was purified by thin-layer chromatography (TLC) and preparative TLC (PTLC) with different solvent systems. RE had higher α-glucosidase and α-amylase inhibitory activity than the five aromatic compounds, while the five aromatic compounds had higher tyrosinase inhibitory activity than RE. The combination of RE/acarbose produced synergic inhibition of α-glucosidase and α-amylase, whereas RE showed additive inhibition of both enzymes when combined with aromatic compounds. The five aromatic compounds showed additive inhibition of tyrosinase when combined with RE. The combination of 2-methoxy-4-vinylphenol/vanillin/guaiacol produced synergistic inhibition of α-amylase while showing antagonism of α-glucosidase and tyrosinase. Interestingly, the RE produced additive inhibition of α-glucosidase, α-amylase and tyrosinase when combined with the 2-methoxy-4-vinylphenol/vanillin/guaiacol combination. RE had rich bioactive compounds related to α-glucosidase, α-amylase and tyrosinase inhibitory activity. Volatile compounds, including 2-methoxy-4-vinylphenol, vanillin and guaiacol, enhanced the inhibitory activity of RE against α-glucosidase, α-amylase and tyrosinase activities. |
| Databáze: | OpenAIRE |
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