Functional evaluation of various ICAM3 transcript variants in diffuse large B-Cell lymphoma

Autor:	Limei Li, Chenglong Yang, null Aruna, Qian Zhou, Xinyu Jiang, Wenfei Du, Chen Liu, Peng Lv, Xiaoliang Wang, Guoying Fan, Shaorong Zhao, Xiaoyuan Zhang, Arong Jin, Wenzhi Shen
Rok vydání:	2022
Předmět:	Gene Expression Regulation Neoplastic Cancer Research Oncology Cell Movement Cell Line Tumor Humans Apoptosis Intercellular Adhesion Molecule-3 Lymphoma Large B-Cell Diffuse Hematology Cell Proliferation
Zdroj:	Leukemia & Lymphoma. 63:2869-2878
ISSN:	1029-2403 1042-8194
DOI:	10.1080/10428194.2022.2092861
Popis:	Previous studies have identified several ICAM3 transcript variants and mainly investigated the function of the longest transcript of ICAM3 in various tumor progressions. However, the role of the other ICAM3 transcript variants remains unclear. Herein, we detected the expression of ICAM3 transcript variants 1-4 in DLBCL cells and tumor tissues, disclosed that variants 1, 3, and 4 were expressed in normal B cell lines and 3 DLBCL cell lines except SU-DHL-2 as well as tumor tissues, while variant 2 was not detected. Moreover, we found that ectopic expression of variants 1-4 enhanced cell proliferation by accelerating the cell cycle in SU-DHL2 cells
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb721afbec0238960785bc4fb5d74b3 https://doi.org/10.1080/10428194.2022.2092861 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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