Increase in the gastrointestinal absorption and in tissue storage of cyclophosphamide in L-1210 leukaemic mice at an advanced stage of the disease
| Autor: | C d'Auteuil, A Barry, J G Lavigne, J M Delâge |
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| Rok vydání: | 1975 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Time Factors Cyclophosphamide medicine.medical_treatment Mice Inbred Strains Spleen Biology Kidney Intestinal absorption Andrology Mice Bone Marrow medicine Animals Leukemia L1210 Lung Chemotherapy Stomach Body Weight Organ Size Small intestine Transplantation medicine.anatomical_structure Adipose Tissue Intestinal Absorption Liver Oncology Gastric Mucosa Bone marrow Neoplasm Transplantation Research Article medicine.drug |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1975.283 |
| Popis: | BDF1 mice were inoculated with 10(6) leukaemic cells and, together with control mice, were given a single oral dose of cyclophosphamide-14C of 100 mg/kg body weight. In the leukaemic mice we observed an increased 14C concentration in the plasma, bone marrow, liver, lungs, spleen, kidney and particularly fat where the level was 2-4 times higher than in control mice. Conversely, during the same period, significantly less 14C was detected in the stomach and small intestine of the leukaemic mice. These results were obtained 6 days after tumour transplantation (median survival time 7.7 days) whereas no differences were observed when the studies were carried out 4 days after tumour transplantation. These findings indicate an increase in the gastrointestinal absorption and in the tissue storage fo cyclophosphamide in L-1210 leukaemic mice at an advanced stage of the disease. |
| Databáze: | OpenAIRE |
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