PHOSPHORYLASE ACTIVITY IN RAT LIVER AND SKELETAL MUSCLE AFTER CATECHOLAMINES
| Autor: | K.R. Hornbrook, T.M. Brody |
|---|---|
| Rok vydání: | 1963 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Epinephrine Phosphorylases Phenoxybenzamine Hexamethonium Compounds Biochemistry Norepinephrine (medication) Hexamethonium compound Glycogen phosphorylase Norepinephrine Catecholamines Internal medicine medicine Ergotamine Muscle Skeletal Pharmacology Chemistry Muscles Research Phosphotransferases Isoproterenol Skeletal muscle Rats medicine.anatomical_structure Endocrinology Metabolism Liver Catecholamine Sympatholytics medicine.drug |
| Zdroj: | Biochemical pharmacology. 12 |
| ISSN: | 0006-2952 |
| Popis: | The time course of liver phosphorylase activation after catecholamine administration and the relative abilities of several adrenergic blocking agents to block catecholamine-induced phosphorylase activation in liver and skeletal muscle was studied in intact anesthetized rats. Subcutaneously injected epinephrine and norepinephrine increased the liver phosphorylase activity, the peak effect occurring 10 min after injection. The liver phosphorylase levels were somewhat reduced 30 min after injection. Isoproterenol administration did not increase the level of rat liver phosphorylase. Blood glucose changes after catecholamine treatment did not mirror the changes in liver phosphorylase activity. Complete blockade of the liver phosphorylase response to epinephrine was observed with the α-adrenergic blocking agent ergotamine. Phenoxybenzamine and two β-adrenergic blocking agents, dichloroisoproterenol and nethalide, gave partial blockade. These data indicate the difficulty in the classification of the liver metabolic receptor. The activation by epinephrine of skeletal muscle phosphorylase appears to be affected only by β-adrenergic blocking agents. |
| Databáze: | OpenAIRE |
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