Investigating the effectiveness, safety and tolerability of quetiapine in the treatment of anorexia nervosa in young people: A pilot study
| Autor: | Andrew Court, Melissa Boasman, Susan J. Weigall, Gregor Berger, Claudia Mulder, Hok Pan Yuen, Patrick D. McGorry, Harry Derham, Sherilyn Goldstone, Chia Huang, Melissa Kerr, Judith Fleming |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Olanzapine Dibenzothiazepines medicine.medical_specialty Pediatrics Anorexia Nervosa Time Factors Adolescent medicine.drug_class Atypical antipsychotic Pilot Projects Anorexia Quetiapine Fumarate Young Adult Clinical Protocols Surveys and Questionnaires mental disorders medicine Humans Psychiatry Biological Psychiatry Psychiatric Status Rating Scales Analysis of Variance medicine.disease Psychotherapy Psychiatry and Mental health Eating disorders Treatment Outcome Tolerability Anorexia nervosa (differential diagnoses) Quetiapine Female medicine.symptom Psychology Antipsychotic Agents Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Psychiatric Research. 44:1027-1034 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2010.03.011 |
| Popis: | To investigate the safety and tolerability of the atypical antipsychotic quetiapine in anorexia nervosa patients, and to determine the effect of quetiapine treatment on anorexic psychopathology and other key outcome measures including weight and body image, we conducted a naturalistic, open-label, 12-week randomized controlled trial of low-dose (100-400 mg/day) quetiapine treatment versus treatment as usual in 33 anorexia nervosa patients from our Eating Disorder Clinics. To monitor the effects of treatment over the medium term, the participants were then followed up with assessment visits at 6 and 12 months after the end of the treatment phase. Low-dose quetiapine treatment resulted in both psychological and physical improvements, with minimal associated side-effects. Given the overall trend toward improvement that we observed, quetiapine appears to be a promising candidate for the treatment of anorexia nervosa. Further large-scale placebo-controlled clinical trials will be necessary to fully evaluate the benefits of quetiapine treatment for this disorder. |
| Databáze: | OpenAIRE |
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