Mapping of SARS-CoV-2 spike protein evolution during the first and second waves of COVID-19 infections in India

Autor:	Vijay Rani Rajpal, Shashi Sharma, Avinash Kumar, Samantha Vaishnavi, Apekshita Singh, Deepmala Sehgal, Mughdha Tiwari, Shailendra Goel, Soom Nath Raina
Rok vydání:	2022
Předmět:	Virology
Zdroj:	Future Virology. 17:557-575
ISSN:	1746-0808 1746-0794
DOI:	10.2217/fvl-2021-0267
Popis:	Aim: The aim of this study was to investigate the SARS-CoV-2 spike protein evolution during the first and second wave of COVID-19 infections in India. Materials & methods: Detailed mutation analysis was done in 763 samples taken from GISAID for the ten most affected Indian states between March 2020 to August 2021. Results: The study revealed 242 mutations corresponding to 207 sites. Fifty-one novel mutations emerged during the assessment period, including many with higher transmissibility and immune evasion functions. Highest number of mutations per spike protein also rose from 5 (first wave) to 13 (second wave). Conclusion: The study identified mutation-rich and no mutation regions in the spike protein. The conserved spike regions can be useful for designing future diagnostics, vaccines and therapeutics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb1fe70b44b2c1499a16072e05332c7 https://doi.org/10.2217/fvl-2021-0267 Zobrazit plný text záznamu