Beta Androstenediol Mitigates the Damage of 1 GeV/n Fe Ion Particle Radiation to the Hematopoietic System
| Autor: | Laura Thompson, Mathew Beckman, David R. Gibb, Francisco Tamariz, Peter Guida, Daniel Contaifer, Roger M. Loria |
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| Rok vydání: | 2011 |
| Předmět: |
Androstenediol
Male Cancer Research Hematopoietic System Injections Subcutaneous Iron Osteoclasts Linear energy transfer Bone Marrow Cells Radiation-Protective Agents Flow cytometry Andrology Mice chemistry.chemical_compound Subcutaneous injection Bone Marrow medicine Animals Heavy Ions Radiology Nuclear Medicine and imaging Pharmacology High-LET Radiation medicine.diagnostic_test Monocyte Original Articles General Medicine Flow Cytometry Mice Inbred C57BL Radiation Injuries Experimental medicine.anatomical_structure Oncology chemistry Immunology Bone marrow Whole-Body Irradiation Ex vivo |
| Zdroj: | Cancer Biotherapy and Radiopharmaceuticals. 26:453-459 |
| ISSN: | 1557-8852 1084-9785 |
| DOI: | 10.1089/cbr.2010.0907 |
| Popis: | Space exploration is associated with exposure to 1-3 Gy solar particle radiation and galactic cosmic radiation that could increase cancer rates. Effective nontoxic countermeasures to high linear energy transfer (LET) radiation exposure are highly desirable but currently not available. The aim was to determine whether a single subcutaneous injection of androstenediol (Δ(5) androsten-3β, 17β-diol [AED]) could mitigate and restore the mouse hematopoetic system from the radiation-mediated injury of 3 Gy whole-body high LET (56)Fe(26+) exposure. The findings show that postradiation AED treatment has an overall positive and significant beneficial effect to restore the levels of hematopoeitic elements (p0.001). Androstenediol treatment significantly increased monocyte levels at days 4, 7, and 14 and, similarly, increased red blood cell, hemoglobin, and platelet counts. Flow cytometry analysis 14 days after radiation and AED treatment demonstrated an increase (p0.05) in bone marrow cells counts. Ex vivo osteoclastogenesis studies show that AED treatment is necessary and advantageous for the development and restoration of osteoclastogenesis after radiation exposure. These findings clearly show that androstenediol functions as a countermeasure to remedy hematopoeitic injury mediated by high LET iron ion radiation. Presently, no other agent has been shown to have such properties. |
| Databáze: | OpenAIRE |
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