Rio Grande do Norte, Brazil, voluntary bone marrow donors registry analysis
| Autor: | Maria do Socorro Belarmino de Oliveira, José Renato Pereira de Moura Barroso, Herton Luiz Alves Sales, M.G. Carvalho, Luiza T. Tsuneto, Anaregina S. Araújo, Luiz Claudio Demes da Mata Sousa, Adalberto Socorro da Silva, Marina Barguil Macêdo, Rosemary Almeida de Oliveira Teixeira, Semiramis Jamil Hadad do Monte, José Machado Moita Neto |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Linkage disequilibrium Multivariate analysis bone marrow Population Biology Linkage Disequilibrium Gene Frequency Bone Marrow Humans Registries HLA antigens Allele education Alleles lcsh:R5-920 education.field_of_study medula óssea HLA-A Antigens Brasil Bone marrow donors Haplotype General Medicine Tissue Donors antígenos HLA Transplantation Haplotypes Turnover HLA-B Antigens Multivariate Analysis Female lcsh:Medicine (General) Brazil transplante Demography HLA-DRB1 Chains transplantation |
| Zdroj: | Revista da Associação Médica Brasileira v.61 n.1 2015 Revista da Associação Médica Brasileira Associação Médica Brasileira (AMB) instacron:AMB Revista da Associação Médica Brasileira, Vol 61, Iss 1, Pp 23-29 (2015) |
| Popis: | Objective: this study aimed to report the allele and haplotype frequencies of volunteer bone marrow donors (VBMD) from the state of Rio Grande do Norte (RN) who were enrolled in the Brazilian Volunteer Bone Marrow Donor Registry (REDOME). Methods: the sample comprised 12,973 VBMD who had their allele and haplotype frequencies calculated by Arlequin 3.5.1.2. A multivariate analysis of the data was obtained through a principal component analysis (PCA) and hierarchical cluster analysis (HCA) performed with SPSS 8.0. Results: the most frequent allelic group was HLA-A*02, followed by -DRB1*13, -DRB1*04, -DRB1*07, -B*44, -B*35, -A*24 and -DRB1*01. Of the 2,701 haplotypes observed, the three most frequent were HLA-A*01 B*08 DRB1*03 (1.62%), -A*29 B*44 DRB1*07 (1.56%) and -A*02 B*44 DRB1*04 (1.29%). These haplotypes were in linkage disequilibrium. RN allele and haplotype frequencies were very similar to those in other Brazilian states in which similar studies have been performed. The PCA revealed that RN is highly genetically similar to Caucasian populations, especially those from Iberian countries, which strongly influenced the state’s ethnic composition. Africans and Amerindians also influenced the RN population structure, to a lesser extent. Conclusion: the HCA reinforced the conclusion that, despite its highly admixed profile, the RN population is genetically similar to European and European-descended populations. The PCA also showed that RN cities do not contribute to the same extent to REDOME, with less populous cities being underrepresented, indicating the need to enroll more VBMD from these smaller cities to faithfully depict the state’s population structure in the database. |
| Databáze: | OpenAIRE |
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