[Effect of long-term treatment with royal jelly on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats]
| Autor: | Naomi Maruo, Yoshito Zamami, Shima Doi, Shingo Takatori, Masataka Nomura, Hiromu Kawasaki |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
food.ingredient Sympathetic Nervous System Systole medicine.medical_treatment Calcitonin Gene-Related Peptide Pharmaceutical Science Vasodilation Calcitonin gene-related peptide In Vitro Techniques food Insulin resistance Internal medicine Diabetes mellitus Royal jelly medicine Animals Insulin Rats Long-Evans Mesenteric arteries Pharmacology business.industry Fatty Acids medicine.disease Mesenteric Arteries Rats Disease Models Animal Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 Vasoconstriction medicine.symptom Insulin Resistance business |
| Zdroj: | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 127(11) |
| ISSN: | 0031-6903 |
| Popis: | Royal jelly (RJ) is known to have abundant nutritional properties and a variety of biological activities. To investigate the effects of RJ on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 diabetic model, were treated for 4 weeks with RJ (10, 30, and 300 mg/kg, p.o.). RJ treatment tended to decrease systolic blood pressure and significantly decreased serum levels of insulin and the Homeostasis Model Assessment ratio, an index of insulin resistance. In isolated and perfused mesenteric vascular beds of OLETF rats, RJ treatment resulted in significant reduction of the sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and potentiation of the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with that in untreated OLETF rats. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that RJ could be an effective and functional food to prevent the development of insulin resistance. |
| Databáze: | OpenAIRE |
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